Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
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[Homology]
Score
CABLES2Cdk5 and Abl enzyme substrate 2. (481 aa)    
Predicted Functional Partners:
ENSCATP00000001548
Protein kinase domain-containing protein.
    
 0.867
CDK5
Cyclin dependent kinase 5; Belongs to the protein kinase superfamily.
    
 0.867
DLK1
Delta like non-canonical Notch ligand 1.
    
   0.842
CDK3
Cyclin dependent kinase 3; Belongs to the protein kinase superfamily.
    
 0.640
CDK2
Cyclin dependent kinase 2; Belongs to the protein kinase superfamily.
    
 0.585
CCNA1
Cyclin A1; Belongs to the cyclin family.
     
 0.584
CCNA2
Cyclin A2; Belongs to the cyclin family.
     
 0.577
CCNE1
Cyclin E1; Belongs to the cyclin family.
    
 0.521
TP53
Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.
    
 
 0.514
CCNE2
Cyclin E2; Belongs to the cyclin family.
    
 0.502
Your Current Organism:
Cercocebus atys
NCBI taxonomy Id: 9531
Other names: C. atys, Cercocebus torquatus atys, sooty mangabey
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