OCA2 protein (Cercocebus atys) - STRING interaction network

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Score

OCA2

OCA2 melanosomal transmembrane protein. (838 aa)

Predicted Functional Partners:

TYR

0.794

GET3

0.773

SLC24A5

0.768

ACP1

0.754

ENSCATP00000016899

0.754

TYRP1

0.706

SLC45A2

0.687

EPAS1

0.618

GPR143

0.617

GLDC

0.592

Your Current Organism:

Cercocebus atys

NCBI taxonomy Id: 9531
Other names: C. atys, Cercocebus torquatus atys, sooty mangabey

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACP1	GET3	ENSCATP00000006287	ENSCATP00000002526	LMWPc domain-containing protein.	ATPase ASNA1; ATPase required for the post-translational delivery of tail- anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. [...]	0.751
ACP1	OCA2	ENSCATP00000006287	ENSCATP00000002010	LMWPc domain-containing protein.	OCA2 melanosomal transmembrane protein.	0.754
ENSCATP00000016899	GET3	ENSCATP00000016899	ENSCATP00000002526	LMWPc domain-containing protein.	ATPase ASNA1; ATPase required for the post-translational delivery of tail- anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. [...]	0.751
ENSCATP00000016899	OCA2	ENSCATP00000016899	ENSCATP00000002010	LMWPc domain-containing protein.	OCA2 melanosomal transmembrane protein.	0.754
EPAS1	OCA2	ENSCATP00000037071	ENSCATP00000002010	Endothelial PAS domain protein 1.	OCA2 melanosomal transmembrane protein.	0.618
EPAS1	SLC24A5	ENSCATP00000037071	ENSCATP00000036674	Endothelial PAS domain protein 1.	Solute carrier family 24 member 5; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.	0.463
GET3	ACP1	ENSCATP00000002526	ENSCATP00000006287	ATPase ASNA1; ATPase required for the post-translational delivery of tail- anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. [...]	LMWPc domain-containing protein.	0.751
GET3	ENSCATP00000016899	ENSCATP00000002526	ENSCATP00000016899	ATPase ASNA1; ATPase required for the post-translational delivery of tail- anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. [...]	LMWPc domain-containing protein.	0.751
GET3	OCA2	ENSCATP00000002526	ENSCATP00000002010	ATPase ASNA1; ATPase required for the post-translational delivery of tail- anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. [...]	OCA2 melanosomal transmembrane protein.	0.773
GET3	SLC24A5	ENSCATP00000002526	ENSCATP00000036674	ATPase ASNA1; ATPase required for the post-translational delivery of tail- anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. [...]	Solute carrier family 24 member 5; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.	0.556
GLDC	OCA2	ENSCATP00000034232	ENSCATP00000002010	Glycine cleavage system P protein; The glycine cleavage system catalyzes the degradation of glycine.	OCA2 melanosomal transmembrane protein.	0.592
GPR143	OCA2	ENSCATP00000016763	ENSCATP00000002010	G protein-coupled receptor 143.	OCA2 melanosomal transmembrane protein.	0.617
GPR143	SLC24A5	ENSCATP00000016763	ENSCATP00000036674	G protein-coupled receptor 143.	Solute carrier family 24 member 5; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.	0.542
GPR143	SLC45A2	ENSCATP00000016763	ENSCATP00000034260	G protein-coupled receptor 143.	Solute carrier family 45 member 2.	0.513
GPR143	TYR	ENSCATP00000016763	ENSCATP00000001686	G protein-coupled receptor 143.	Tyrosinase.	0.847
GPR143	TYRP1	ENSCATP00000016763	ENSCATP00000044932	G protein-coupled receptor 143.	Tyrosinase related protein 1.	0.575
OCA2	ACP1	ENSCATP00000002010	ENSCATP00000006287	OCA2 melanosomal transmembrane protein.	LMWPc domain-containing protein.	0.754
OCA2	ENSCATP00000016899	ENSCATP00000002010	ENSCATP00000016899	OCA2 melanosomal transmembrane protein.	LMWPc domain-containing protein.	0.754
OCA2	EPAS1	ENSCATP00000002010	ENSCATP00000037071	OCA2 melanosomal transmembrane protein.	Endothelial PAS domain protein 1.	0.618
OCA2	GET3	ENSCATP00000002010	ENSCATP00000002526	OCA2 melanosomal transmembrane protein.	ATPase ASNA1; ATPase required for the post-translational delivery of tail- anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. [...]	0.773