node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CYP51A1 | HMGCR | ENSCATP00000007678 | ENSCATP00000004012 | Cytochrome P450 family 51 subfamily A member 1; Belongs to the cytochrome P450 family. | 3-hydroxy-3-methylglutaryl coenzyme A reductase. | 0.917 |
CYP51A1 | HMGCS1 | ENSCATP00000007678 | ENSCATP00000031649 | Cytochrome P450 family 51 subfamily A member 1; Belongs to the cytochrome P450 family. | 3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. | 0.920 |
CYP51A1 | HMGCS2 | ENSCATP00000007678 | ENSCATP00000016879 | Cytochrome P450 family 51 subfamily A member 1; Belongs to the cytochrome P450 family. | 3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. | 0.905 |
CYP51A1 | MVD | ENSCATP00000007678 | ENSCATP00000016176 | Cytochrome P450 family 51 subfamily A member 1; Belongs to the cytochrome P450 family. | Diphosphomevalonate decarboxylase; Performs the first committed step in the biosynthesis of isoprenes. | 0.864 |
CYP51A1 | MVK | ENSCATP00000007678 | ENSCATP00000002206 | Cytochrome P450 family 51 subfamily A member 1; Belongs to the cytochrome P450 family. | Mevalonate kinase; Catalyzes the phosphorylation of mevalonate to mevalonate 5- phosphate, a key step in isoprenoid and cholesterol biosynthesis. Belongs to the GHMP kinase family. Mevalonate kinase subfamily. | 0.584 |
CYP51A1 | SQLE | ENSCATP00000007678 | ENSCATP00000019523 | Cytochrome P450 family 51 subfamily A member 1; Belongs to the cytochrome P450 family. | Squalene epoxidase. | 0.976 |
HMGCR | CYP51A1 | ENSCATP00000004012 | ENSCATP00000007678 | 3-hydroxy-3-methylglutaryl coenzyme A reductase. | Cytochrome P450 family 51 subfamily A member 1; Belongs to the cytochrome P450 family. | 0.917 |
HMGCR | HMGCS1 | ENSCATP00000004012 | ENSCATP00000031649 | 3-hydroxy-3-methylglutaryl coenzyme A reductase. | 3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. | 0.993 |
HMGCR | HMGCS2 | ENSCATP00000004012 | ENSCATP00000016879 | 3-hydroxy-3-methylglutaryl coenzyme A reductase. | 3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. | 0.991 |
HMGCR | MVD | ENSCATP00000004012 | ENSCATP00000016176 | 3-hydroxy-3-methylglutaryl coenzyme A reductase. | Diphosphomevalonate decarboxylase; Performs the first committed step in the biosynthesis of isoprenes. | 0.920 |
HMGCR | MVK | ENSCATP00000004012 | ENSCATP00000002206 | 3-hydroxy-3-methylglutaryl coenzyme A reductase. | Mevalonate kinase; Catalyzes the phosphorylation of mevalonate to mevalonate 5- phosphate, a key step in isoprenoid and cholesterol biosynthesis. Belongs to the GHMP kinase family. Mevalonate kinase subfamily. | 0.964 |
HMGCR | PRKAA1 | ENSCATP00000004012 | ENSCATP00000033734 | 3-hydroxy-3-methylglutaryl coenzyme A reductase. | Non-specific serine/threonine protein kinase. | 0.907 |
HMGCR | PRKAA2 | ENSCATP00000004012 | ENSCATP00000036138 | 3-hydroxy-3-methylglutaryl coenzyme A reductase. | Non-specific serine/threonine protein kinase. | 0.907 |
HMGCR | PRKAG2 | ENSCATP00000004012 | ENSCATP00000039588 | 3-hydroxy-3-methylglutaryl coenzyme A reductase. | Protein kinase AMP-activated non-catalytic subunit gamma 2. | 0.906 |
HMGCR | PRKAG3 | ENSCATP00000004012 | ENSCATP00000040494 | 3-hydroxy-3-methylglutaryl coenzyme A reductase. | Protein kinase AMP-activated non-catalytic subunit gamma 3. | 0.916 |
HMGCR | SQLE | ENSCATP00000004012 | ENSCATP00000019523 | 3-hydroxy-3-methylglutaryl coenzyme A reductase. | Squalene epoxidase. | 0.922 |
HMGCS1 | CYP51A1 | ENSCATP00000031649 | ENSCATP00000007678 | 3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. | Cytochrome P450 family 51 subfamily A member 1; Belongs to the cytochrome P450 family. | 0.920 |
HMGCS1 | HMGCR | ENSCATP00000031649 | ENSCATP00000004012 | 3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. | 3-hydroxy-3-methylglutaryl coenzyme A reductase. | 0.993 |
HMGCS1 | HMGCS2 | ENSCATP00000031649 | ENSCATP00000016879 | 3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. | 3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. | 0.894 |
HMGCS1 | MVD | ENSCATP00000031649 | ENSCATP00000016176 | 3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. | Diphosphomevalonate decarboxylase; Performs the first committed step in the biosynthesis of isoprenes. | 0.885 |