PGR protein (Cercocebus atys) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene fusion

Co-occurrence

Co-expression

Experiments

Databases

Textmining

[Homology]

Score

PGR

Progesterone receptor. (933 aa)

Predicted Functional Partners:

ESR1

0.988

NCOA1

0.988

NCOA3

0.975

FKBP4

0.971

SRC

0.964

PIK3CA

0.939

FKBP5

0.936

PIK3CB

0.931

PIK3CD

0.931

ESR2

0.929

Your Current Organism:

Cercocebus atys

NCBI taxonomy Id: 9531
Other names: C. atys, Cercocebus torquatus atys, sooty mangabey

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc.

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ESR1	ESR2	ENSCATP00000012127	ENSCATP00000026097	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Estrogen receptor 2.	0.999
ESR1	FKBP4	ENSCATP00000012127	ENSCATP00000022744	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Peptidylprolyl isomerase.	0.652
ESR1	FKBP5	ENSCATP00000012127	ENSCATP00000008100	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Peptidylprolyl isomerase.	0.666
ESR1	NCOA1	ENSCATP00000012127	ENSCATP00000025009	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Nuclear receptor coactivator.	0.996
ESR1	NCOA3	ENSCATP00000012127	ENSCATP00000025120	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Nuclear receptor coactivator.	0.998
ESR1	PGR	ENSCATP00000012127	ENSCATP00000010231	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Progesterone receptor.	0.988
ESR1	PIK3CA	ENSCATP00000012127	ENSCATP00000027089	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.918
ESR1	PIK3CB	ENSCATP00000012127	ENSCATP00000024233	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family.	0.727
ESR1	PIK3CD	ENSCATP00000012127	ENSCATP00000038140	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.726
ESR1	SRC	ENSCATP00000012127	ENSCATP00000004115	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Tyrosine-protein kinase.	0.996
ESR2	ESR1	ENSCATP00000026097	ENSCATP00000012127	Estrogen receptor 2.	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	0.999
ESR2	FKBP4	ENSCATP00000026097	ENSCATP00000022744	Estrogen receptor 2.	Peptidylprolyl isomerase.	0.614
ESR2	FKBP5	ENSCATP00000026097	ENSCATP00000008100	Estrogen receptor 2.	Peptidylprolyl isomerase.	0.531
ESR2	NCOA1	ENSCATP00000026097	ENSCATP00000025009	Estrogen receptor 2.	Nuclear receptor coactivator.	0.994
ESR2	NCOA3	ENSCATP00000026097	ENSCATP00000025120	Estrogen receptor 2.	Nuclear receptor coactivator.	0.996
ESR2	PGR	ENSCATP00000026097	ENSCATP00000010231	Estrogen receptor 2.	Progesterone receptor.	0.929
ESR2	PIK3CA	ENSCATP00000026097	ENSCATP00000027089	Estrogen receptor 2.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.745
ESR2	PIK3CB	ENSCATP00000026097	ENSCATP00000024233	Estrogen receptor 2.	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family.	0.652
ESR2	PIK3CD	ENSCATP00000026097	ENSCATP00000038140	Estrogen receptor 2.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.652
ESR2	SRC	ENSCATP00000026097	ENSCATP00000004115	Estrogen receptor 2.	Tyrosine-protein kinase.	0.989