STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
INSRRTyrosine-protein kinase receptor. (1296 aa)    
Predicted Functional Partners:
INS
Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.
    
 0.973
IGF1
Insulin like growth factor 1.
    
 0.944
PTPN1
Tyrosine-protein phosphatase non-receptor type.
    
 0.922
GRB2
Growth factor receptor bound protein 2.
   
 0.913
SOS1
SOS Ras/Rac guanine nucleotide exchange factor 1.
    
 0.889
SOS2
SOS Ras/Rho guanine nucleotide exchange factor 2.
    
 0.887
PIK3R2
Uncharacterized protein.
    
 0.885
PIK3R3
Phosphoinositide-3-kinase regulatory subunit 3.
    
 0.885
PIK3R1
Phosphoinositide-3-kinase regulatory subunit 1.
    
 0.885
IGF1R
Tyrosine-protein kinase receptor.
  
 
0.880
Your Current Organism:
Cercocebus atys
NCBI taxonomy Id: 9531
Other names: C. atys, Cercocebus torquatus atys, sooty mangabey
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