Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
INSRRTyrosine-protein kinase receptor. (1296 aa)    
Predicted Functional Partners:
INS
Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.
    
 0.991
GRB2
Growth factor receptor bound protein 2.
    
 0.955
SOS1
SOS Ras/Rac guanine nucleotide exchange factor 1.
    
 0.947
IGF1
Insulin like growth factor 1.
    
 0.946
SOS2
SOS Ras/Rho guanine nucleotide exchange factor 2.
    
 0.937
PTPN1
Tyrosine-protein phosphatase non-receptor type.
    
 0.929
PIK3R2
Uncharacterized protein.
    
 0.873
PIK3R3
Phosphoinositide-3-kinase regulatory subunit 3.
    
 0.873
PIK3R1
Phosphoinositide-3-kinase regulatory subunit 1.
    
 0.873
ESR1
Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.
    
 0.861
Your Current Organism:
Cercocebus atys
NCBI taxonomy Id: 9531
Other names: C. atys, Cercocebus torquatus atys, sooty mangabey
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