OGG1 protein (Cercocebus atys) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene fusion

Co-occurrence

Co-expression

Experiments

Databases

Textmining

[Homology]

Score

OGG1

8-oxoguanine DNA glycosylase. (401 aa)

Predicted Functional Partners:

NEIL1

0.889

APEX1

0.879

POLH

0.849

NTHL1

0.779

POLI

0.773

ENSCATP00000023486

0.763

ENSCATP00000024396

0.763

NT5E

0.761

NEIL2

0.753

FANCM

0.750

Your Current Organism:

Cercocebus atys

NCBI taxonomy Id: 9531
Other names: C. atys, Cercocebus torquatus atys, sooty mangabey

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc.

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APEX1	FANCM	ENSCATP00000004453	ENSCATP00000014720	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.	FA complementation group M.	0.693
APEX1	NEIL1	ENSCATP00000004453	ENSCATP00000020297	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.	Nei like DNA glycosylase 1.	0.455
APEX1	NEIL2	ENSCATP00000004453	ENSCATP00000027268	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.	Nei like DNA glycosylase 2.	0.423
APEX1	NTHL1	ENSCATP00000004453	ENSCATP00000035084	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.	Endonuclease III-like protein 1; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines.	0.991
APEX1	OGG1	ENSCATP00000004453	ENSCATP00000010328	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.	8-oxoguanine DNA glycosylase.	0.879
ENSCATP00000023486	ENSCATP00000024396	ENSCATP00000023486	ENSCATP00000024396	PWWP domain-containing protein.	DNA_MISMATCH_REPAIR_2 domain-containing protein.	0.897
ENSCATP00000023486	FANCM	ENSCATP00000023486	ENSCATP00000014720	PWWP domain-containing protein.	FA complementation group M.	0.857
ENSCATP00000023486	OGG1	ENSCATP00000023486	ENSCATP00000010328	PWWP domain-containing protein.	8-oxoguanine DNA glycosylase.	0.763
ENSCATP00000023486	POLH	ENSCATP00000023486	ENSCATP00000036973	PWWP domain-containing protein.	DNA polymerase eta.	0.526
ENSCATP00000023486	POLI	ENSCATP00000023486	ENSCATP00000018452	PWWP domain-containing protein.	DNA polymerase iota.	0.421
ENSCATP00000024396	ENSCATP00000023486	ENSCATP00000024396	ENSCATP00000023486	DNA_MISMATCH_REPAIR_2 domain-containing protein.	PWWP domain-containing protein.	0.897
ENSCATP00000024396	FANCM	ENSCATP00000024396	ENSCATP00000014720	DNA_MISMATCH_REPAIR_2 domain-containing protein.	FA complementation group M.	0.857
ENSCATP00000024396	OGG1	ENSCATP00000024396	ENSCATP00000010328	DNA_MISMATCH_REPAIR_2 domain-containing protein.	8-oxoguanine DNA glycosylase.	0.763
ENSCATP00000024396	POLH	ENSCATP00000024396	ENSCATP00000036973	DNA_MISMATCH_REPAIR_2 domain-containing protein.	DNA polymerase eta.	0.526
ENSCATP00000024396	POLI	ENSCATP00000024396	ENSCATP00000018452	DNA_MISMATCH_REPAIR_2 domain-containing protein.	DNA polymerase iota.	0.421
FANCM	APEX1	ENSCATP00000014720	ENSCATP00000004453	FA complementation group M.	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.	0.693
FANCM	ENSCATP00000023486	ENSCATP00000014720	ENSCATP00000023486	FA complementation group M.	PWWP domain-containing protein.	0.857
FANCM	ENSCATP00000024396	ENSCATP00000014720	ENSCATP00000024396	FA complementation group M.	DNA_MISMATCH_REPAIR_2 domain-containing protein.	0.857
FANCM	NTHL1	ENSCATP00000014720	ENSCATP00000035084	FA complementation group M.	Endonuclease III-like protein 1; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines.	0.720
FANCM	OGG1	ENSCATP00000014720	ENSCATP00000010328	FA complementation group M.	8-oxoguanine DNA glycosylase.	0.750