NUDT12 protein (Cercocebus atys) - STRING interaction network

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Score

NUDT12

Nudix hydrolase 12. (462 aa)

Predicted Functional Partners:

SIRT5

0.992

NMNAT3

0.992

NMRK1

0.992

NMNAT2

0.992

NAPRT

0.915

NADK2

0.909

QPRT

0.909

NT5C2

0.905

SIRT2

0.903

SIRT4

0.903

Your Current Organism:

Cercocebus atys

NCBI taxonomy Id: 9531
Other names: C. atys, Cercocebus torquatus atys, sooty mangabey

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
NADK2	NMNAT2	ENSCATP00000012926	ENSCATP00000023053	NAD kinase 2, mitochondrial; Mitochondrial NAD(+) kinase that phosphorylates NAD(+) to yield NADP(+). Can use both ATP or inorganic polyphosphate as the phosphoryl donor.	Nicotinamide nucleotide adenylyltransferase 2.	0.993
NADK2	NMNAT3	ENSCATP00000012926	ENSCATP00000014036	NAD kinase 2, mitochondrial; Mitochondrial NAD(+) kinase that phosphorylates NAD(+) to yield NADP(+). Can use both ATP or inorganic polyphosphate as the phosphoryl donor.	Nicotinamide-nucleotide adenylyltransferase.	0.994
NADK2	NUDT12	ENSCATP00000012926	ENSCATP00000010573	NAD kinase 2, mitochondrial; Mitochondrial NAD(+) kinase that phosphorylates NAD(+) to yield NADP(+). Can use both ATP or inorganic polyphosphate as the phosphoryl donor.	Nudix hydrolase 12.	0.909
NAPRT	NMNAT2	ENSCATP00000016089	ENSCATP00000023053	Nicotinate phosphoribosyltransferase; Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Belongs to the NAPRTase family.	Nicotinamide nucleotide adenylyltransferase 2.	0.942
NAPRT	NMNAT3	ENSCATP00000016089	ENSCATP00000014036	Nicotinate phosphoribosyltransferase; Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Belongs to the NAPRTase family.	Nicotinamide-nucleotide adenylyltransferase.	0.946
NAPRT	NMRK1	ENSCATP00000016089	ENSCATP00000017534	Nicotinate phosphoribosyltransferase; Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Belongs to the NAPRTase family.	Nicotinamide riboside kinase 1.	0.945
NAPRT	NUDT12	ENSCATP00000016089	ENSCATP00000010573	Nicotinate phosphoribosyltransferase; Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Belongs to the NAPRTase family.	Nudix hydrolase 12.	0.915
NAPRT	QPRT	ENSCATP00000016089	ENSCATP00000019229	Nicotinate phosphoribosyltransferase; Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Belongs to the NAPRTase family.	Nicotinate-nucleotide pyrophosphorylase [carboxylating]; Involved in the catabolism of quinolinic acid (QA). Belongs to the NadC/ModD family.	0.959
NAPRT	SIRT2	ENSCATP00000016089	ENSCATP00000011378	Nicotinate phosphoribosyltransferase; Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Belongs to the NAPRTase family.	NAD-dependent protein deacetylase; NAD-dependent protein deacetylase.	0.428
NAPRT	SIRT4	ENSCATP00000016089	ENSCATP00000020842	Nicotinate phosphoribosyltransferase; Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Belongs to the NAPRTase family.	NAD-dependent protein lipoamidase sirtuin-4, mitochondrial; Acts as NAD-dependent protein lipoamidase, ADP-ribosyl transferase and deacetylase. Catalyzes more efficiently removal of lipoyl- and biotinyl- than acetyl-lysine modifications. Inhibits the pyruvate dehydrogenase complex (PDH) activity via the enzymatic hydrolysis of the lipoamide cofactor from the E2 component, DLAT, in a phosphorylation-independent manner. Catalyzes the transfer of ADP- ribosyl groups onto target proteins, including mitochondrial GLUD1, inhibiting GLUD1 enzyme activity. Acts as a negative regulator of mitoc [...]	0.446
NAPRT	SIRT5	ENSCATP00000016089	ENSCATP00000004356	Nicotinate phosphoribosyltransferase; Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Belongs to the NAPRTase family.	NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting. Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species. Modulates ketogenesis through the desuccinyl [...]	0.454
NMNAT2	NADK2	ENSCATP00000023053	ENSCATP00000012926	Nicotinamide nucleotide adenylyltransferase 2.	NAD kinase 2, mitochondrial; Mitochondrial NAD(+) kinase that phosphorylates NAD(+) to yield NADP(+). Can use both ATP or inorganic polyphosphate as the phosphoryl donor.	0.993
NMNAT2	NAPRT	ENSCATP00000023053	ENSCATP00000016089	Nicotinamide nucleotide adenylyltransferase 2.	Nicotinate phosphoribosyltransferase; Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Belongs to the NAPRTase family.	0.942
NMNAT2	NMNAT3	ENSCATP00000023053	ENSCATP00000014036	Nicotinamide nucleotide adenylyltransferase 2.	Nicotinamide-nucleotide adenylyltransferase.	0.992
NMNAT2	NMRK1	ENSCATP00000023053	ENSCATP00000017534	Nicotinamide nucleotide adenylyltransferase 2.	Nicotinamide riboside kinase 1.	0.996
NMNAT2	NT5C2	ENSCATP00000023053	ENSCATP00000013417	Nicotinamide nucleotide adenylyltransferase 2.	5'-nucleotidase, cytosolic II.	0.992
NMNAT2	NUDT12	ENSCATP00000023053	ENSCATP00000010573	Nicotinamide nucleotide adenylyltransferase 2.	Nudix hydrolase 12.	0.992
NMNAT2	QPRT	ENSCATP00000023053	ENSCATP00000019229	Nicotinamide nucleotide adenylyltransferase 2.	Nicotinate-nucleotide pyrophosphorylase [carboxylating]; Involved in the catabolism of quinolinic acid (QA). Belongs to the NadC/ModD family.	0.995
NMNAT2	SIRT2	ENSCATP00000023053	ENSCATP00000011378	Nicotinamide nucleotide adenylyltransferase 2.	NAD-dependent protein deacetylase; NAD-dependent protein deacetylase.	0.935
NMNAT2	SIRT4	ENSCATP00000023053	ENSCATP00000020842	Nicotinamide nucleotide adenylyltransferase 2.	NAD-dependent protein lipoamidase sirtuin-4, mitochondrial; Acts as NAD-dependent protein lipoamidase, ADP-ribosyl transferase and deacetylase. Catalyzes more efficiently removal of lipoyl- and biotinyl- than acetyl-lysine modifications. Inhibits the pyruvate dehydrogenase complex (PDH) activity via the enzymatic hydrolysis of the lipoamide cofactor from the E2 component, DLAT, in a phosphorylation-independent manner. Catalyzes the transfer of ADP- ribosyl groups onto target proteins, including mitochondrial GLUD1, inhibiting GLUD1 enzyme activity. Acts as a negative regulator of mitoc [...]	0.928