ERBB3 protein (Cercocebus atys) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene fusion

Co-occurrence

Co-expression

Experiments

Databases

Textmining

[Homology]

Score

ERBB3

Erb-b2 receptor tyrosine kinase 3. (1349 aa)

Predicted Functional Partners:

NRG1

0.998

NRG2

0.998

ERBB2

0.997

GRB2

0.996

PIK3R1

0.995

PIK3CA

0.993

PIK3R2

0.992

EGF

0.992

EGFR

0.991

ERBB4

0.989

Your Current Organism:

Cercocebus atys

NCBI taxonomy Id: 9531
Other names: C. atys, Cercocebus torquatus atys, sooty mangabey

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc.

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EGF	EGFR	ENSCATP00000037054	ENSCATP00000033478	Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6.	Receptor protein-tyrosine kinase.	0.999
EGF	ERBB2	ENSCATP00000037054	ENSCATP00000008001	Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6.	Receptor protein-tyrosine kinase.	0.996
EGF	ERBB3	ENSCATP00000037054	ENSCATP00000010580	Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6.	Erb-b2 receptor tyrosine kinase 3.	0.992
EGF	ERBB4	ENSCATP00000037054	ENSCATP00000041332	Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6.	Receptor protein-tyrosine kinase.	0.972
EGF	GRB2	ENSCATP00000037054	ENSCATP00000042750	Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6.	Growth factor receptor bound protein 2.	0.690
EGF	NRG1	ENSCATP00000037054	ENSCATP00000029591	Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6.	Neuregulin 1.	0.739
EGF	NRG2	ENSCATP00000037054	ENSCATP00000043909	Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6.	Neuregulin 2.	0.643
EGF	PIK3CA	ENSCATP00000037054	ENSCATP00000027089	Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.818
EGF	PIK3R1	ENSCATP00000037054	ENSCATP00000027907	Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6.	Phosphoinositide-3-kinase regulatory subunit 1.	0.688
EGF	PIK3R2	ENSCATP00000037054	ENSCATP00000023918	Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6.	Uncharacterized protein.	0.557
EGFR	EGF	ENSCATP00000033478	ENSCATP00000037054	Receptor protein-tyrosine kinase.	Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6.	0.999
EGFR	ERBB2	ENSCATP00000033478	ENSCATP00000008001	Receptor protein-tyrosine kinase.	Receptor protein-tyrosine kinase.	0.995
EGFR	ERBB3	ENSCATP00000033478	ENSCATP00000010580	Receptor protein-tyrosine kinase.	Erb-b2 receptor tyrosine kinase 3.	0.991
EGFR	ERBB4	ENSCATP00000033478	ENSCATP00000041332	Receptor protein-tyrosine kinase.	Receptor protein-tyrosine kinase.	0.945
EGFR	GRB2	ENSCATP00000033478	ENSCATP00000042750	Receptor protein-tyrosine kinase.	Growth factor receptor bound protein 2.	0.999
EGFR	NRG1	ENSCATP00000033478	ENSCATP00000029591	Receptor protein-tyrosine kinase.	Neuregulin 1.	0.996
EGFR	NRG2	ENSCATP00000033478	ENSCATP00000043909	Receptor protein-tyrosine kinase.	Neuregulin 2.	0.995
EGFR	PIK3CA	ENSCATP00000033478	ENSCATP00000027089	Receptor protein-tyrosine kinase.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.998
EGFR	PIK3R1	ENSCATP00000033478	ENSCATP00000027907	Receptor protein-tyrosine kinase.	Phosphoinositide-3-kinase regulatory subunit 1.	0.997
EGFR	PIK3R2	ENSCATP00000033478	ENSCATP00000023918	Receptor protein-tyrosine kinase.	Uncharacterized protein.	0.994