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The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
NLRP2NLR family pyrin domain containing 2. (1048 aa)    
Predicted Functional Partners:
PYCARD
PYD and CARD domain containing.
   
 0.820
NLRP1
NLR family pyrin domain containing 1.
    
0.668
CASP1
Caspase 1; Belongs to the peptidase C14A family.
   
 0.630
MEFV
MEFV innate immuity regulator, pyrin.
   
 0.612
LOC105595225
FIIND domain-containing protein.
 
 
 0.587
NLRC4
NLR family CARD domain containing 4.
   
 
0.579
CASP5
Caspase 5; Belongs to the peptidase C14A family.
   
 0.552
IL1B
Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family.
   
 0.537
AIM2
Absent in melanoma 2.
      
 0.524
NLRP12
NLR family pyrin domain containing 12.
    
 
0.495
Your Current Organism:
Cercocebus atys
NCBI taxonomy Id: 9531
Other names: C. atys, Cercocebus torquatus atys, sooty mangabey
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