Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
CTC1CST telomere replication complex component 1. (1217 aa)    
Predicted Functional Partners:
TEN1
Uncharacterized protein.
    
 0.998
STN1
CST complex subunit STN1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication.
    
 0.996
POT1
Protection of telomeres 1.
    
 0.977
POLA1
DNA polymerase.
   
 0.933
TINF2
TERF1 interacting nuclear factor 2.
     
 0.914
ENSCATP00000026110
Uncharacterized protein.
    
 0.900
POLA2
DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis.
    
 0.889
PRIM1
DNA primase; Belongs to the eukaryotic-type primase small subunit family.
    
 0.870
TERF1
Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat.
     
 0.856
ENSCATP00000020493
Uncharacterized protein.
    
 0.847
Your Current Organism:
Cercocebus atys
NCBI taxonomy Id: 9531
Other names: C. atys, Cercocebus torquatus atys, sooty mangabey
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