node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ENSCATP00000013881 | LOC105581285 | ENSCATP00000013881 | ENSCATP00000012836 | GOLD domain-containing protein. | GOLD domain-containing protein; Belongs to the EMP24/GP25L family. | 0.981 |
ENSCATP00000013881 | TMED10 | ENSCATP00000013881 | ENSCATP00000014354 | GOLD domain-containing protein. | Transmembrane p24 trafficking protein 10. | 0.981 |
ENSCATP00000013881 | TMED3 | ENSCATP00000013881 | ENSCATP00000036063 | GOLD domain-containing protein. | Transmembrane p24 trafficking protein 3. | 0.892 |
ENSCATP00000013881 | TMED4 | ENSCATP00000013881 | ENSCATP00000027078 | GOLD domain-containing protein. | Transmembrane p24 trafficking protein 4. | 0.938 |
IRF3 | TLR3 | ENSCATP00000034413 | ENSCATP00000011052 | Interferon regulatory factor 3. | Toll like receptor 3; Belongs to the Toll-like receptor family. | 0.847 |
IRF3 | TLR4 | ENSCATP00000034413 | ENSCATP00000041789 | Interferon regulatory factor 3. | Toll like receptor 4; Belongs to the Toll-like receptor family. | 0.810 |
IRF3 | TMED3 | ENSCATP00000034413 | ENSCATP00000036063 | Interferon regulatory factor 3. | Transmembrane p24 trafficking protein 3. | 0.808 |
IRF3 | TRAF6 | ENSCATP00000034413 | ENSCATP00000012971 | Interferon regulatory factor 3. | TNF receptor-associated factor 6; E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Mediates activation of NF-kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B-lymphocytes. Adapter protein that seems to [...] | 0.711 |
LOC105581285 | ENSCATP00000013881 | ENSCATP00000012836 | ENSCATP00000013881 | GOLD domain-containing protein; Belongs to the EMP24/GP25L family. | GOLD domain-containing protein. | 0.981 |
LOC105581285 | TMED2 | ENSCATP00000012836 | ENSCATP00000029231 | GOLD domain-containing protein; Belongs to the EMP24/GP25L family. | Transmembrane p24 trafficking protein 2. | 0.981 |
LOC105581285 | TMED3 | ENSCATP00000012836 | ENSCATP00000036063 | GOLD domain-containing protein; Belongs to the EMP24/GP25L family. | Transmembrane p24 trafficking protein 3. | 0.875 |
LOC105581285 | TMED4 | ENSCATP00000012836 | ENSCATP00000027078 | GOLD domain-containing protein; Belongs to the EMP24/GP25L family. | Transmembrane p24 trafficking protein 4. | 0.954 |
MAP3K7 | TLR3 | ENSCATP00000042911 | ENSCATP00000011052 | Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. | Toll like receptor 3; Belongs to the Toll-like receptor family. | 0.943 |
MAP3K7 | TLR4 | ENSCATP00000042911 | ENSCATP00000041789 | Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. | Toll like receptor 4; Belongs to the Toll-like receptor family. | 0.961 |
MAP3K7 | TMED3 | ENSCATP00000042911 | ENSCATP00000036063 | Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. | Transmembrane p24 trafficking protein 3. | 0.805 |
MAP3K7 | TRAF6 | ENSCATP00000042911 | ENSCATP00000012971 | Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. | TNF receptor-associated factor 6; E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Mediates activation of NF-kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B-lymphocytes. Adapter protein that seems to [...] | 0.996 |
TLR3 | IRF3 | ENSCATP00000011052 | ENSCATP00000034413 | Toll like receptor 3; Belongs to the Toll-like receptor family. | Interferon regulatory factor 3. | 0.847 |
TLR3 | MAP3K7 | ENSCATP00000011052 | ENSCATP00000042911 | Toll like receptor 3; Belongs to the Toll-like receptor family. | Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. | 0.943 |
TLR3 | TLR4 | ENSCATP00000011052 | ENSCATP00000041789 | Toll like receptor 3; Belongs to the Toll-like receptor family. | Toll like receptor 4; Belongs to the Toll-like receptor family. | 0.790 |
TLR3 | TMED3 | ENSCATP00000011052 | ENSCATP00000036063 | Toll like receptor 3; Belongs to the Toll-like receptor family. | Transmembrane p24 trafficking protein 3. | 0.846 |