node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CENPX | ENSCATP00000036401 | ENSCATP00000027910 | ENSCATP00000036401 | Centromere protein X. | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. | 0.961 |
CENPX | ENSCATP00000041476 | ENSCATP00000027910 | ENSCATP00000041476 | Centromere protein X. | NTF2 domain-containing protein. | 0.824 |
CENPX | FAAP24 | ENSCATP00000027910 | ENSCATP00000028210 | Centromere protein X. | FA core complex associated protein 24. | 0.990 |
CENPX | FANCB | ENSCATP00000027910 | ENSCATP00000022472 | Centromere protein X. | FA complementation group B. | 0.832 |
CENPX | FANCC | ENSCATP00000027910 | ENSCATP00000013745 | Centromere protein X. | Fanconi anemia group C protein homolog; DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Upon IFNG induction, may facilitate STAT1 activation by recruiting STAT1 to IFNGR1. | 0.986 |
CENPX | FANCG | ENSCATP00000027910 | ENSCATP00000011352 | Centromere protein X. | FA complementation group G. | 0.986 |
CENPX | FANCL | ENSCATP00000027910 | ENSCATP00000032083 | Centromere protein X. | FA complementation group L. | 0.986 |
CENPX | FANCM | ENSCATP00000027910 | ENSCATP00000014720 | Centromere protein X. | FA complementation group M. | 0.996 |
ENSCATP00000036401 | CENPX | ENSCATP00000036401 | ENSCATP00000027910 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. | Centromere protein X. | 0.961 |
ENSCATP00000036401 | ENSCATP00000041476 | ENSCATP00000036401 | ENSCATP00000041476 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. | NTF2 domain-containing protein. | 0.812 |
ENSCATP00000036401 | FAAP24 | ENSCATP00000036401 | ENSCATP00000028210 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. | FA core complex associated protein 24. | 0.754 |
ENSCATP00000036401 | FANCC | ENSCATP00000036401 | ENSCATP00000013745 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. | Fanconi anemia group C protein homolog; DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Upon IFNG induction, may facilitate STAT1 activation by recruiting STAT1 to IFNGR1. | 0.606 |
ENSCATP00000036401 | FANCG | ENSCATP00000036401 | ENSCATP00000011352 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. | FA complementation group G. | 0.960 |
ENSCATP00000036401 | FANCM | ENSCATP00000036401 | ENSCATP00000014720 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. | FA complementation group M. | 0.999 |
ENSCATP00000041476 | CENPX | ENSCATP00000041476 | ENSCATP00000027910 | NTF2 domain-containing protein. | Centromere protein X. | 0.824 |
ENSCATP00000041476 | ENSCATP00000036401 | ENSCATP00000041476 | ENSCATP00000036401 | NTF2 domain-containing protein. | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. | 0.812 |
ENSCATP00000041476 | FAAP24 | ENSCATP00000041476 | ENSCATP00000028210 | NTF2 domain-containing protein. | FA core complex associated protein 24. | 0.876 |
ENSCATP00000041476 | FANCB | ENSCATP00000041476 | ENSCATP00000022472 | NTF2 domain-containing protein. | FA complementation group B. | 0.878 |
ENSCATP00000041476 | FANCC | ENSCATP00000041476 | ENSCATP00000013745 | NTF2 domain-containing protein. | Fanconi anemia group C protein homolog; DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Upon IFNG induction, may facilitate STAT1 activation by recruiting STAT1 to IFNGR1. | 0.876 |
ENSCATP00000041476 | FANCG | ENSCATP00000041476 | ENSCATP00000011352 | NTF2 domain-containing protein. | FA complementation group G. | 0.904 |