STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
whiAConserved hypothetical protein; Involved in cell division and chromosome segregation. Plays a central role in the initiation of sporulation through the activation of multiple components of the cell division machinery. Acts as a transcriptional regulator that is involved in the direct control of genes required for key steps in sporulation, including the cessation of aerial growth, the initiation of cell division, and chromosome segregation. Functions almost equally as an activator and as a repressor. Required for DNA binding by WhiB. May function cooperatively with WhiB ; Belongs to the [...] (327 aa)    
Predicted Functional Partners:
SVEN_1579
Hypothetical protein; Required for morphogenesis under gluconeogenic growth conditions; Belongs to the gluconeogenesis factor family.
 
  
 0.971
ftsZ
Cell division protein FtsZ; Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
     
 0.949
SVEN_1580
Hypothetical ATP-binding protein; Displays ATPase and GTPase activities.
 
  
 0.941
SVEN_1573
Preprotein translocase subunit SecG; Involved in protein export. Participates in an early event of protein translocation; Belongs to the SecG family.
 
   
 0.911
uvrC
Excinuclease ABC subunit C; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.
 
     0.898
SVEN_0965
Hypothetical protein.
  
   
 0.888
crgA
Putative WhiP protein; Involved in cell division; Belongs to the CrgA family.
  
   
 0.884
fbiA
Phosphoenolpyruvate transferase; Catalyzes the transfer of the phosphoenolpyruvate moiety from enoylpyruvoyl-2-diphospho-5'-guanosine (EPPG) to 7,8-didemethyl-8- hydroxy-5-deazariboflavin (FO) with the formation of dehydro coenzyme F420-0 and GMP.
  
  
 0.883
SVEN_5300
RNA polymerase sigma factor for flagellar operon; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.
      
 0.871
pgk
Phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family.
 
  
 0.837
Your Current Organism:
Streptomyces venezuelae
NCBI taxonomy Id: 953739
Other names: S. venezuelae ATCC 10712, Streptomyces venezuelae ATCC 10712, Streptomyces venezuelae ISP 5230, Streptomyces venezuelae str. ATCC 10712, Streptomyces venezuelae strain ATCC 10712
Server load: low (28%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.