Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
PRSS22Serine protease 22; Belongs to the peptidase S1 family. (261 aa)    
Predicted Functional Partners:
KCNU1
Potassium channel subfamily U member 1; Testis-specific potassium channel activated by both intracellular pH and membrane voltage that mediates export of K(+). May represent the primary spermatozoan K(+) current. In contrast to KCNMA1/SLO1, it is not activated by Ca(2+) or Mg(2+). Critical for fertility. May play an important role in sperm osmoregulation required for the acquisition of normal morphology and motility when faced with osmotic challenges, such as those experienced after mixing with seminal fluid and entry into the vagina (By similarity); Belongs to the potassium channel fa [...]
    
 
 0.691
CYP2S1
Cytochrome P450 family 2 subfamily S member 1; Belongs to the cytochrome P450 family.
    
 
 0.628
OR6C1
Olfactory receptor.
    
 0.625
KLK10
Kallikrein related peptidase 10; Belongs to the peptidase S1 family.
  
    0.541
LOC102128231
Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family.
  
 
0.513
LOC102147021
Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family.
  
0.487
CTRB2
Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family.
  
0.483
CTRL
Chymotrypsin like; Belongs to the peptidase S1 family.
  
0.454
IAH1
Isoamyl acetate hydrolyzing esterase 1 (putative).
      
 0.436
PRCP
Prolylcarboxypeptidase.
   
 
 0.434
Your Current Organism:
Macaca fascicularis
NCBI taxonomy Id: 9541
Other names: M. fascicularis, Macaca cynomolgus, Macaca irus, crab eating macaque, crab-eating macaque, cynomolgus macaque, cynomolgus monkey, cynomolgus monkeys, long-tailed macaque
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