Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
PLEKHG4BPleckstrin homology and RhoGEF domain containing G4B. (1581 aa)    
Predicted Functional Partners:
ARHGEF11
Rho guanine nucleotide exchange factor 11.
     
 0.648
PCYT2
Phosphate cytidylyltransferase 2, ethanolamine.
      
 0.559
ARHGEF19
Rho guanine nucleotide exchange factor 19.
     
 0.533
ARHGEF33
Rho guanine nucleotide exchange factor 33.
   
 
 0.525
RASGRF2
Ras protein specific guanine nucleotide releasing factor 2.
     
 0.518
PPWD1
Peptidylprolyl isomerase domain and WD repeat containing 1.
      
 0.516
PLEKHG6
Pleckstrin homology and RhoGEF domain containing G6.
     
 0.493
LOC102145186
Uncharacterized protein.
      
 0.471
GLYATL1
Glycine-N-acyltransferase like 1.
      
 0.471
CNN1
Calponin; Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity.
    
 
 0.469
Your Current Organism:
Macaca fascicularis
NCBI taxonomy Id: 9541
Other names: M. fascicularis, Macaca cynomolgus, Macaca irus, crab eating macaque, crab-eating macaque, cynomolgus macaque, cynomolgus monkey, cynomolgus monkeys, long-tailed macaque
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