Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Experiments
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[Homology]
Score
ITPK1Inositol-tetrakisphosphate 1-kinase. (414 aa)    
Predicted Functional Partners:
MINPP1
Multiple inositol-polyphosphate phosphatase 1; Belongs to the histidine acid phosphatase family.
     
 0.957
IPPK
Inositol-pentakisphosphate 2-kinase; Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate).
     
 0.956
IPMK
Kinase; Belongs to the inositol phosphokinase (IPK) family.
     
 0.950
INPP5J
Inositol polyphosphate-5-phosphatase J.
     
 0.941
INPP5K
Inositol polyphosphate-5-phosphatase K.
     
 0.930
INPP4A
Inositol polyphosphate-4-phosphatase type I A.
    
 0.912
INPP4B
Type II inositol 3,4-bisphosphate 4-phosphatase; Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate, inositol 1,3,4-trisphosphate and inositol 3,4-bisphosphate (By similarity). Plays a role in the late stages of macropinocytosis by dephosphorylating phosphatidylinositol 3,4-bisphosphate in membrane ruffles (By similarity). The lipid phosphatase activity is critical for tumor suppressor function. Antagonizes the PI3K-AKT/PKB signaling pathway by dephosphorylating phosphoinositides and thereby modulating cell cycle progression and cell survival [...]
    
 0.911
ITPKB
Kinase; Belongs to the inositol phosphokinase (IPK) family.
     
 0.911
ITPKA
Kinase; Belongs to the inositol phosphokinase (IPK) family.
     
 0.910
LOC102129084
Uncharacterized protein.
     
 0.905
Your Current Organism:
Macaca fascicularis
NCBI taxonomy Id: 9541
Other names: M. fascicularis, Macaca cynomolgus, Macaca irus, crab eating macaque, crab-eating macaque, cynomolgus macaque, cynomolgus monkey, cynomolgus monkeys, long-tailed macaque
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