Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (328 aa)    
Predicted Functional Partners:
IL23A
Interleukin 23 p19 subunit.
  
 0.999
IL12A
Interleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC.
   
 0.999
IL12RB1
Interleukin 12 receptor subunit beta 1.
   
 0.992
IL23R
Interleukin 23 receptor.
   
 0.991
JAK2
Tyrosine-protein kinase.
   
 0.988
IL12RB2
Interleukin 12 receptor subunit beta 2.
   
 0.976
TYK2
Tyrosine-protein kinase.
   
 0.973
STAT3
Signal transducer and activator of transcription.
    
 0.927
IL6ST
Interleukin 6 signal transducer.
   
 0.856
P4HB
Protein disulfide-isomerase.
   
  0.823
Your Current Organism:
Macaca fascicularis
NCBI taxonomy Id: 9541
Other names: M. fascicularis, Macaca cynomolgus, Macaca irus, crab eating macaque, crab-eating macaque, cynomolgus macaque, cynomolgus monkey, cynomolgus monkeys, long-tailed macaque
Server load: low (16%) [HD]