Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
FXR1FMR1 autosomal homolog 1. (779 aa)    
Predicted Functional Partners:
FXR2
FMR1 autosomal homolog 2.
   
 
 0.984
FMR1
Fragile X mental retardation 1.
   
 
 0.934
CAPRIN1
Cell cycle associated protein 1.
   
 
 0.932
UBAP2L
Ubiquitin associated protein 2 like.
    
 
 0.924
AGO2
Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]
    
 
 0.847
TDRD3
Tudor domain containing 3.
    
 
 0.846
ENSMFAP00000001201
Uncharacterized protein.
   
 
 0.834
G3BP1
G3BP stress granule assembly factor 1.
   
 
 0.834
G3BP2
G3BP stress granule assembly factor 2.
   
 
 0.778
CYFIP2
Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family.
    
 
 0.777
Your Current Organism:
Macaca fascicularis
NCBI taxonomy Id: 9541
Other names: M. fascicularis, Macaca cynomolgus, Macaca irus, crab eating macaque, crab-eating macaque, cynomolgus macaque, cynomolgus monkey, cynomolgus monkeys, long-tailed macaque
Server load: low (18%) [HD]