SPTLC2 protein (Macaca fascicularis) - STRING interaction network

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SPTLC2

Serine palmitoyltransferase long chain base subunit 2. (555 aa)

Predicted Functional Partners:

SPTLC1

0.997

SPTSSA

0.995

KDSR

0.980

SPTSSB

0.976

ORMDL3

0.972

SPTLC3

0.929

SHMT2

0.826

SHMT1

0.826

CBS

0.825

AGXT

0.822

Your Current Organism:

Macaca fascicularis

NCBI taxonomy Id: 9541
Other names: M. fascicularis, Macaca cynomolgus, Macaca irus, crab eating macaque, crab-eating macaque, cynomolgus macaque, cynomolgus monkey, cynomolgus monkeys, long-tailed macaque

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AGXT	CBS	ENSMFAP00000029236	ENSMFAP00000038933	Serine--pyruvate aminotransferase.	Cystathionine beta-synthase; Hydro-lyase catalyzing the first step of the transsulfuration pathway, where the hydroxyl group of L-serine is displaced by L- homocysteine in a beta-replacement reaction to form L-cystathionine, the precursor of L-cysteine. This catabolic route allows the elimination of L-methionine and the toxic metabolite L-homocysteine (By similarity). Also involved in the production of hydrogen sulfide, a gasotransmitter with signaling and cytoprotective effects on neurons (By similarity).	0.923
AGXT	SHMT1	ENSMFAP00000029236	ENSMFAP00000036572	Serine--pyruvate aminotransferase.	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family.	0.991
AGXT	SHMT2	ENSMFAP00000029236	ENSMFAP00000004919	Serine--pyruvate aminotransferase.	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family.	0.987
AGXT	SPTLC1	ENSMFAP00000029236	ENSMFAP00000013660	Serine--pyruvate aminotransferase.	Serine palmitoyltransferase 1; Serine palmitoyltransferase (SPT). The heterodimer formed with SPTLC2 or SPTLC3 constitutes the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC3-SPTSSA isozyme uses both C14-CoA and C16-CoA as substrates, with a slight preference for C14-CoA. The SPTLC1-SPTLC2-SPTSSB complex shows a strong preference for C18-CoA substrate, while the SPTLC1-SPTLC3-SPTSSB isozyme displays an ability to [...]	0.822
AGXT	SPTLC2	ENSMFAP00000029236	ENSMFAP00000001215	Serine--pyruvate aminotransferase.	Serine palmitoyltransferase long chain base subunit 2.	0.822
AGXT	SPTLC3	ENSMFAP00000029236	ENSMFAP00000026967	Serine--pyruvate aminotransferase.	Serine palmitoyltransferase long chain base subunit 3.	0.822
CBS	AGXT	ENSMFAP00000038933	ENSMFAP00000029236	Cystathionine beta-synthase; Hydro-lyase catalyzing the first step of the transsulfuration pathway, where the hydroxyl group of L-serine is displaced by L- homocysteine in a beta-replacement reaction to form L-cystathionine, the precursor of L-cysteine. This catabolic route allows the elimination of L-methionine and the toxic metabolite L-homocysteine (By similarity). Also involved in the production of hydrogen sulfide, a gasotransmitter with signaling and cytoprotective effects on neurons (By similarity).	Serine--pyruvate aminotransferase.	0.923
CBS	SHMT1	ENSMFAP00000038933	ENSMFAP00000036572	Cystathionine beta-synthase; Hydro-lyase catalyzing the first step of the transsulfuration pathway, where the hydroxyl group of L-serine is displaced by L- homocysteine in a beta-replacement reaction to form L-cystathionine, the precursor of L-cysteine. This catabolic route allows the elimination of L-methionine and the toxic metabolite L-homocysteine (By similarity). Also involved in the production of hydrogen sulfide, a gasotransmitter with signaling and cytoprotective effects on neurons (By similarity).	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family.	0.939
CBS	SHMT2	ENSMFAP00000038933	ENSMFAP00000004919	Cystathionine beta-synthase; Hydro-lyase catalyzing the first step of the transsulfuration pathway, where the hydroxyl group of L-serine is displaced by L- homocysteine in a beta-replacement reaction to form L-cystathionine, the precursor of L-cysteine. This catabolic route allows the elimination of L-methionine and the toxic metabolite L-homocysteine (By similarity). Also involved in the production of hydrogen sulfide, a gasotransmitter with signaling and cytoprotective effects on neurons (By similarity).	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family.	0.937
CBS	SPTLC1	ENSMFAP00000038933	ENSMFAP00000013660	Cystathionine beta-synthase; Hydro-lyase catalyzing the first step of the transsulfuration pathway, where the hydroxyl group of L-serine is displaced by L- homocysteine in a beta-replacement reaction to form L-cystathionine, the precursor of L-cysteine. This catabolic route allows the elimination of L-methionine and the toxic metabolite L-homocysteine (By similarity). Also involved in the production of hydrogen sulfide, a gasotransmitter with signaling and cytoprotective effects on neurons (By similarity).	Serine palmitoyltransferase 1; Serine palmitoyltransferase (SPT). The heterodimer formed with SPTLC2 or SPTLC3 constitutes the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC3-SPTSSA isozyme uses both C14-CoA and C16-CoA as substrates, with a slight preference for C14-CoA. The SPTLC1-SPTLC2-SPTSSB complex shows a strong preference for C18-CoA substrate, while the SPTLC1-SPTLC3-SPTSSB isozyme displays an ability to [...]	0.825
CBS	SPTLC2	ENSMFAP00000038933	ENSMFAP00000001215	Cystathionine beta-synthase; Hydro-lyase catalyzing the first step of the transsulfuration pathway, where the hydroxyl group of L-serine is displaced by L- homocysteine in a beta-replacement reaction to form L-cystathionine, the precursor of L-cysteine. This catabolic route allows the elimination of L-methionine and the toxic metabolite L-homocysteine (By similarity). Also involved in the production of hydrogen sulfide, a gasotransmitter with signaling and cytoprotective effects on neurons (By similarity).	Serine palmitoyltransferase long chain base subunit 2.	0.825
CBS	SPTLC3	ENSMFAP00000038933	ENSMFAP00000026967	Cystathionine beta-synthase; Hydro-lyase catalyzing the first step of the transsulfuration pathway, where the hydroxyl group of L-serine is displaced by L- homocysteine in a beta-replacement reaction to form L-cystathionine, the precursor of L-cysteine. This catabolic route allows the elimination of L-methionine and the toxic metabolite L-homocysteine (By similarity). Also involved in the production of hydrogen sulfide, a gasotransmitter with signaling and cytoprotective effects on neurons (By similarity).	Serine palmitoyltransferase long chain base subunit 3.	0.825
KDSR	SPTLC1	ENSMFAP00000009793	ENSMFAP00000013660	3-ketodihydrosphingosine reductase; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	Serine palmitoyltransferase 1; Serine palmitoyltransferase (SPT). The heterodimer formed with SPTLC2 or SPTLC3 constitutes the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC3-SPTSSA isozyme uses both C14-CoA and C16-CoA as substrates, with a slight preference for C14-CoA. The SPTLC1-SPTLC2-SPTSSB complex shows a strong preference for C18-CoA substrate, while the SPTLC1-SPTLC3-SPTSSB isozyme displays an ability to [...]	0.992
KDSR	SPTLC2	ENSMFAP00000009793	ENSMFAP00000001215	3-ketodihydrosphingosine reductase; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	Serine palmitoyltransferase long chain base subunit 2.	0.980
KDSR	SPTLC3	ENSMFAP00000009793	ENSMFAP00000026967	3-ketodihydrosphingosine reductase; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	Serine palmitoyltransferase long chain base subunit 3.	0.980
ORMDL3	SPTLC1	ENSMFAP00000013237	ENSMFAP00000013660	ORM1-like protein; Negative regulator of sphingolipid synthesis.	Serine palmitoyltransferase 1; Serine palmitoyltransferase (SPT). The heterodimer formed with SPTLC2 or SPTLC3 constitutes the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC3-SPTSSA isozyme uses both C14-CoA and C16-CoA as substrates, with a slight preference for C14-CoA. The SPTLC1-SPTLC2-SPTSSB complex shows a strong preference for C18-CoA substrate, while the SPTLC1-SPTLC3-SPTSSB isozyme displays an ability to [...]	0.972
ORMDL3	SPTLC2	ENSMFAP00000013237	ENSMFAP00000001215	ORM1-like protein; Negative regulator of sphingolipid synthesis.	Serine palmitoyltransferase long chain base subunit 2.	0.972
ORMDL3	SPTLC3	ENSMFAP00000013237	ENSMFAP00000026967	ORM1-like protein; Negative regulator of sphingolipid synthesis.	Serine palmitoyltransferase long chain base subunit 3.	0.917
ORMDL3	SPTSSA	ENSMFAP00000013237	ENSMFAP00000007162	ORM1-like protein; Negative regulator of sphingolipid synthesis.	Serine palmitoyltransferase small subunit A.	0.953
SHMT1	AGXT	ENSMFAP00000036572	ENSMFAP00000029236	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family.	Serine--pyruvate aminotransferase.	0.991

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