Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
CCN2Connective tissue growth factor. (349 aa)    
Predicted Functional Partners:
TGFB2
Transforming growth factor beta; Belongs to the TGF-beta family.
   
  
 0.799
COL1A1
Collagen type I alpha 1 chain.
   
  
 0.764
TGFB1
Transforming growth factor beta; Belongs to the TGF-beta family.
   
  
 0.739
ANKRD1
Ankyrin repeat domain 1.
   
 
 0.738
MMP9
Matrix metallopeptidase 9.
   
 
 0.725
IL6
Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...]
   
  
 0.717
TGFB3
Transforming growth factor beta; Belongs to the TGF-beta family.
   
  
 0.698
LATS1
Large tumor suppressor kinase 1.
      
 0.689
SMAD2
Mothers against decapentaplegic homolog.
   
 
 0.655
SERPINE1
Serpin family E member 1; Belongs to the serpin family.
   
 
 0.648
Your Current Organism:
Macaca fascicularis
NCBI taxonomy Id: 9541
Other names: M. fascicularis, Macaca cynomolgus, Macaca irus, crab eating macaque, crab-eating macaque, cynomolgus macaque, cynomolgus monkey, cynomolgus monkeys, long-tailed macaque
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