Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
TNFRSF9TNF receptor superfamily member 9. (254 aa)    
Predicted Functional Partners:
TNFSF9
TNF superfamily member 9; Belongs to the tumor necrosis factor family.
    
 0.998
TRAF2
TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.
   
 
 0.916
TRAF1
TNF receptor-associated factor.
   
 
 0.837
CD4
T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...]
   
  
 0.827
CTLA4
Cytotoxic T-lymphocyte associated protein 4.
   
  
 0.739
ICOS
Inducible T cell costimulator.
   
  
 0.727
CD27
CD27 molecule.
   
  
 0.725
LAG3
Lymphocyte activating 3.
   
  
 0.704
TRAF3
TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.
   
 
 0.702
CD247
Uncharacterized protein.
   
  
 0.695
Your Current Organism:
Macaca fascicularis
NCBI taxonomy Id: 9541
Other names: M. fascicularis, Macaca cynomolgus, Macaca irus, crab eating macaque, crab-eating macaque, cynomolgus macaque, cynomolgus monkey, cynomolgus monkeys, long-tailed macaque
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