Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
PAXIP1PAX interacting protein 1. (1087 aa)    
Predicted Functional Partners:
PAGR1
PAXIP1 associated glutamate rich protein 1.
    
 0.993
KMT2D
Lysine methyltransferase 2D.
   
 0.987
RBBP5
RB binding protein 5, histone lysine methyltransferase complex subunit.
   
 0.986
ASH2L
ASH2 like, histone lysine methyltransferase complex subunit.
    
 0.985
WDR5
WD repeat domain 5.
    
 0.980
TP53BP1
Tumor protein p53 binding protein 1.
   
 0.971
NCOA6
Nuclear receptor coactivator 6.
   
 0.970
KMT2C
Lysine methyltransferase 2C.
   
 0.961
DPY30
Dpy-30 histone methyltransferase complex regulatory subunit.
    
 0.936
ATM
Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]
   
 0.915
Your Current Organism:
Macaca fascicularis
NCBI taxonomy Id: 9541
Other names: M. fascicularis, Macaca cynomolgus, Macaca irus, crab eating macaque, crab-eating macaque, cynomolgus macaque, cynomolgus monkey, cynomolgus monkeys, long-tailed macaque
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