Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
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PYCR1Pyrroline-5-carboxylate reductase; Belongs to the pyrroline-5-carboxylate reductase family. (346 aa)    
Predicted Functional Partners:
PYCR2
Pyrroline-5-carboxylate reductase 2; Housekeeping enzyme that catalyzes the last step in proline biosynthesis. In some cell types, such as erythrocytes, its primary function may be the generation of NADP(+). Can utilize both NAD and NADP. Has higher affinity for NADP, but higher catalytic efficiency with NADH (By similarity). Involved in cellular response to oxidative stress (By similarity); Belongs to the pyrroline-5-carboxylate reductase family.
  
 
0.992
PYCR3
Pyrroline-5-carboxylate reductase 3; Enzyme that catalyzes the last step in proline biosynthesis. Proline is synthesized from either glutamate or ornithine; both are converted to pyrroline-5-carboxylate (P5C), and then to proline via pyrroline-5-carboxylate reductases (PYCRs). PYCRL is exclusively linked to the conversion of ornithine to proline.
  
 
 
0.990
ALDH4A1
Delta-1-pyrroline-5-carboxylate dehydrogenase; Belongs to the aldehyde dehydrogenase family.
   
 
 0.939
ENSMFAP00000004595
Uncharacterized protein.
   
   0.930
PRODH2
Proline dehydrogenase; Converts proline to delta-1-pyrroline-5-carboxylate.
   
 0.926
P4HA1
Prolyl 4-hydroxylase subunit alpha 1.
     
 0.905
P4HA3
Prolyl 4-hydroxylase subunit alpha 3.
     
 0.905
P4HA2
Prolyl 4-hydroxylase subunit alpha 2.
     
 0.905
LAP3
Leucine aminopeptidase 3.
    
 0.905
NUDT5
Nudix hydrolase 5; Belongs to the Nudix hydrolase family.
   
   0.904
Your Current Organism:
Macaca fascicularis
NCBI taxonomy Id: 9541
Other names: M. fascicularis, Macaca cynomolgus, Macaca irus, crab eating macaque, crab-eating macaque, cynomolgus macaque, cynomolgus monkey, cynomolgus monkeys, long-tailed macaque
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