Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
DESDesmin; Belongs to the intermediate filament family. (470 aa)    
Predicted Functional Partners:
VIM
Vimentin; Vimentins are class-III intermediate filaments found in various non-epithelial cells, especially mesenchymal cells. Vimentin is attached to the nucleus, endoplasmic reticulum, and mitochondria, either laterally or terminally.
   
  0.980
NEFH
Neurofilament heavy; Belongs to the intermediate filament family.
   
 0.936
NEFL
Neurofilament light; Belongs to the intermediate filament family.
   
 0.922
PRPH
Peripherin; Belongs to the intermediate filament family.
   
   0.918
NEFM
Neurofilament medium; Belongs to the intermediate filament family.
   
 0.916
SYNC
Syncoilin, intermediate filament protein; Belongs to the intermediate filament family.
   
 0.901
GFAP
Glial fibrillary acidic protein; Belongs to the intermediate filament family.
   
  0.889
KRT7
Keratin 7; Belongs to the intermediate filament family.
    
   0.829
SYNM
Synemin; Belongs to the intermediate filament family.
   
 
 0.786
PLEC
Plectin.
   
 0.739
Your Current Organism:
Macaca fascicularis
NCBI taxonomy Id: 9541
Other names: M. fascicularis, Macaca cynomolgus, Macaca irus, crab eating macaque, crab-eating macaque, cynomolgus macaque, cynomolgus monkey, cynomolgus monkeys, long-tailed macaque
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