Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
GRB2Growth factor receptor-binding protein 2. (217 aa)    
Predicted Functional Partners:
PTK2
Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family.
   
 0.999
SOS2
SOS Ras/Rho guanine nucleotide exchange factor 2.
    
 0.999
SOS1
SOS Ras/Rac guanine nucleotide exchange factor 1.
    
 0.999
GAB1
GRB2 associated binding protein 1.
    
 0.999
EGFR
Receptor protein-tyrosine kinase.
    
 0.999
FRS2
Fibroblast growth factor receptor substrate 2.
    
 0.998
LCP2
Lymphocyte cytosolic protein 2.
   
 0.998
ERBB4
Receptor protein-tyrosine kinase.
    
 0.997
ERBB2
Receptor protein-tyrosine kinase.
    
 0.997
IRS1
Insulin receptor substrate 1.
    
 0.997
Your Current Organism:
Macaca fascicularis
NCBI taxonomy Id: 9541
Other names: M. fascicularis, Macaca cynomolgus, Macaca irus, crab eating macaque, crab-eating macaque, cynomolgus macaque, cynomolgus monkey, cynomolgus monkeys, long-tailed macaque
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