Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
PPYPancreatic polypeptide. (95 aa)    
Predicted Functional Partners:
NPY4R
G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.
    
 0.984
NPY2R
Neuropeptide Y receptor Y2; Belongs to the G-protein coupled receptor 1 family.
   
 0.979
NPY1R
Neuropeptide Y receptor Y1; Belongs to the G-protein coupled receptor 1 family.
    
 0.978
PYY
Peptide YY.
  
 
0.976
NPY5R
Neuropeptide Y receptor Y5.
    
 0.963
NPY
Neuropeptide Y.
  
 
0.959
GPR83
G protein-coupled receptor 83; Belongs to the G-protein coupled receptor 1 family.
    
  0.900
CEL
Carboxyl ester lipase; Belongs to the type-B carboxylesterase/lipase family.
   
  0.845
GCG
Glucagon.
   
 
 0.838
SST
Somatostatin-14; [Somatostatin-14]: Inhibits the secretion of pituitary hormones, including that of growth hormone/somatotropin (GH1), PRL, ACTH, luteinizing hormone (LH) and TSH. Also impairs ghrelin- and GnRH- stimulated secretion of GH1 and LH; the inhibition of ghrelin- stimulated secretion of GH1 can be further increased by neuronostatin.
     
 0.835
Your Current Organism:
Macaca fascicularis
NCBI taxonomy Id: 9541
Other names: M. fascicularis, Macaca cynomolgus, Macaca irus, crab eating macaque, crab-eating macaque, cynomolgus macaque, cynomolgus monkey, cynomolgus monkeys, long-tailed macaque
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