Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
HNRNPKHeterogeneous nuclear ribonucleoprotein K; One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single-stranded DNA. Plays an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression. When sumoylated, acts as a transcriptional coactivator of p53/TP53, playing a role in p21/CDKN1A and 14-3-3 sigma/SFN induction. As far as transcription repression is co [...] (464 aa)    
Predicted Functional Partners:
HNRNPA2B1
Uncharacterized protein.
   
 0.972
HNRNPL
Uncharacterized protein.
   
 0.942
HNRNPU
Heterogeneous nuclear ribonucleoprotein U.
   
 0.927
PCBP1
Poly(rC) binding protein 1.
   
 0.888
PTBP1
Polypyrimidine tract binding protein 1.
   
 0.885
HNRNPM
Heterogeneous nuclear ribonucleoprotein M.
   
 0.880
HNRNPD
Heterogeneous nuclear ribonucleoprotein D.
   
 0.876
KHDRBS1
KH domain-containing protein.
   
 
 0.844
HNRNPA0
Heterogeneous nuclear ribonucleoprotein A0.
   
 0.837
HNRNPDL
Heterogeneous nuclear ribonucleoprotein D like.
   
 0.829
Your Current Organism:
Macaca fascicularis
NCBI taxonomy Id: 9541
Other names: M. fascicularis, Macaca cynomolgus, Macaca irus, crab eating macaque, crab-eating macaque, cynomolgus macaque, cynomolgus monkey, cynomolgus monkeys, long-tailed macaque
Server load: low (14%) [HD]