Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
E2F4E2F transcription factor 4. (416 aa)    
Predicted Functional Partners:
RBL1
RB transcriptional corepressor like 1.
   
 0.999
RBL2
RB transcriptional corepressor like 2.
   
 0.998
TFDP2
Transcription factor.
   
 0.997
RB1
RB transcriptional corepressor 1.
   
 0.995
TFDP1
Transcription factor.
   
 0.990
LIN9
Protein lin-9 homolog; Acts as a tumor suppressor. Inhibits DNA synthesis. Its ability to inhibit oncogenic transformation is mediated through its association with RB1. Plays a role in the expression of genes required for the G1/S transition (By similarity).
    
 0.989
SMAD4
Mothers against decapentaplegic homolog.
    
 0.980
LIN37
Lin-37 DREAM MuvB core complex component.
    
 0.977
SMAD3
Mothers against decapentaplegic homolog.
    
 0.974
SMAD2
Mothers against decapentaplegic homolog.
    
 0.968
Your Current Organism:
Macaca fascicularis
NCBI taxonomy Id: 9541
Other names: M. fascicularis, Macaca cynomolgus, Macaca irus, crab eating macaque, crab-eating macaque, cynomolgus macaque, cynomolgus monkey, cynomolgus monkeys, long-tailed macaque
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