Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
MSH5DNA_MISMATCH_REPAIR_2 domain-containing protein. (833 aa)    
Predicted Functional Partners:
MSH4
MutS homolog 4.
   
 0.991
MLH3
MutL homolog 3.
  
 0.913
MLH1
MutL homolog 1.
  
 0.895
PMS1
PMS1 homolog 1, mismatch repair system component.
  
 0.825
TOP3A
DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family.
  
 0.806
BLM
BLM RecQ like helicase.
  
 0.802
PMS2
PMS1 homolog 2, mismatch repair system component.
  
 0.775
ABL1
ABL proto-oncogene 1, non-receptor tyrosine kinase.
    
   0.770
BRCA2
BRCA2 DNA repair associated.
   
 
 0.712
MND1
Meiotic nuclear division protein 1 homolog; Required for proper homologous chromosome pairing and efficient cross-over and intragenic recombination during meiosis. Belongs to the MND1 family.
   
  
 0.694
Your Current Organism:
Macaca fascicularis
NCBI taxonomy Id: 9541
Other names: M. fascicularis, Macaca cynomolgus, Macaca irus, crab eating macaque, crab-eating macaque, cynomolgus macaque, cynomolgus monkey, cynomolgus monkeys, long-tailed macaque
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