Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
HNRNPUHeterogeneous nuclear ribonucleoprotein U. (825 aa)    
Predicted Functional Partners:
HNRNPA2B1
Uncharacterized protein.
   
 0.982
HNRNPD
Heterogeneous nuclear ribonucleoprotein D.
   
 0.981
HNRNPL
Uncharacterized protein.
   
 0.979
DHX9
DExH-box helicase 9.
   
 0.970
HNRNPA0
Heterogeneous nuclear ribonucleoprotein A0.
   
 0.958
HNRNPDL
Heterogeneous nuclear ribonucleoprotein D like.
   
 0.950
HNRNPM
Heterogeneous nuclear ribonucleoprotein M.
   
 0.943
SYNCRIP
Uncharacterized protein.
   
 0.942
ENSMFAP00000000260
Uncharacterized protein.
   
 0.927
HNRNPK
Heterogeneous nuclear ribonucleoprotein K; One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single-stranded DNA. Plays an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression. When sumoylated, acts as a transcriptional coactivator of p53/TP53, playing a role in p21/CDKN1A and 14-3-3 sigma/SFN induction. As far as transcription repression is co [...]
   
 0.927
Your Current Organism:
Macaca fascicularis
NCBI taxonomy Id: 9541
Other names: M. fascicularis, Macaca cynomolgus, Macaca irus, crab eating macaque, crab-eating macaque, cynomolgus macaque, cynomolgus monkey, cynomolgus monkeys, long-tailed macaque
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