| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CD4 | ENSMFAP00000002011 | ENSMFAP00000041028 | ENSMFAP00000002011 | T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...] | Uncharacterized protein. | 0.456 |
| CD4 | IFNAR1 | ENSMFAP00000041028 | ENSMFAP00000024004 | T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...] | Interferon alpha and beta receptor subunit 1. | 0.711 |
| CD4 | IFNG | ENSMFAP00000041028 | ENSMFAP00000024297 | T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...] | Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. | 0.995 |
| CD4 | IL2 | ENSMFAP00000041028 | ENSMFAP00000021866 | T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...] | Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells (By similarity); Belongs to the IL-2 family. | 0.987 |
| CD4 | ISG15 | ENSMFAP00000041028 | ENSMFAP00000041264 | T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...] | ISG15 ubiquitin like modifier. | 0.742 |
| ENSMFAP00000002011 | CD4 | ENSMFAP00000002011 | ENSMFAP00000041028 | Uncharacterized protein. | T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...] | 0.456 |
| ENSMFAP00000002011 | IFNAR1 | ENSMFAP00000002011 | ENSMFAP00000024004 | Uncharacterized protein. | Interferon alpha and beta receptor subunit 1. | 0.581 |
| ENSMFAP00000002011 | IFNAR2 | ENSMFAP00000002011 | ENSMFAP00000044454 | Uncharacterized protein. | Uncharacterized protein. | 0.581 |
| ENSMFAP00000002011 | IFNG | ENSMFAP00000002011 | ENSMFAP00000024297 | Uncharacterized protein. | Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. | 0.434 |
| ENSMFAP00000002011 | IL2 | ENSMFAP00000002011 | ENSMFAP00000021866 | Uncharacterized protein. | Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells (By similarity); Belongs to the IL-2 family. | 0.512 |
| ENSMFAP00000002011 | ISG15 | ENSMFAP00000002011 | ENSMFAP00000041264 | Uncharacterized protein. | ISG15 ubiquitin like modifier. | 0.649 |
| ENSMFAP00000002011 | RNASE6 | ENSMFAP00000002011 | ENSMFAP00000010073 | Uncharacterized protein. | Ribonuclease A family member k6; Belongs to the pancreatic ribonuclease family. | 0.427 |
| IFNAR1 | CD4 | ENSMFAP00000024004 | ENSMFAP00000041028 | Interferon alpha and beta receptor subunit 1. | T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...] | 0.711 |
| IFNAR1 | ENSMFAP00000002011 | ENSMFAP00000024004 | ENSMFAP00000002011 | Interferon alpha and beta receptor subunit 1. | Uncharacterized protein. | 0.581 |
| IFNAR1 | IFNAR2 | ENSMFAP00000024004 | ENSMFAP00000044454 | Interferon alpha and beta receptor subunit 1. | Uncharacterized protein. | 0.997 |
| IFNAR1 | IFNG | ENSMFAP00000024004 | ENSMFAP00000024297 | Interferon alpha and beta receptor subunit 1. | Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. | 0.956 |
| IFNAR1 | IL2 | ENSMFAP00000024004 | ENSMFAP00000021866 | Interferon alpha and beta receptor subunit 1. | Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells (By similarity); Belongs to the IL-2 family. | 0.733 |
| IFNAR1 | ISG15 | ENSMFAP00000024004 | ENSMFAP00000041264 | Interferon alpha and beta receptor subunit 1. | ISG15 ubiquitin like modifier. | 0.599 |
| IFNAR2 | ENSMFAP00000002011 | ENSMFAP00000044454 | ENSMFAP00000002011 | Uncharacterized protein. | Uncharacterized protein. | 0.581 |
| IFNAR2 | IFNAR1 | ENSMFAP00000044454 | ENSMFAP00000024004 | Uncharacterized protein. | Interferon alpha and beta receptor subunit 1. | 0.997 |