| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ASAH1 | CERS1 | ENSMFAP00000045035 | ENSMFAP00000027134 | Acid ceramidase subunit alpha; Lysosomal ceramidase that hydrolyzes sphingolipid ceramides into sphingosine and free fatty acids at acidic pH (By similarity). Ceramides, sphingosine, and its phosphorylated form sphingosine-1- phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation (By similarity). Has a higher catalytic efficiency towards C12-ceramides versus other ceramides (By similarity). Also catalyzes the reverse reaction allowing the synthesis of ceramides from fatt [...] | TLC domain-containing protein. | 0.929 |
| ASAH1 | CERS2 | ENSMFAP00000045035 | ENSMFAP00000038504 | Acid ceramidase subunit alpha; Lysosomal ceramidase that hydrolyzes sphingolipid ceramides into sphingosine and free fatty acids at acidic pH (By similarity). Ceramides, sphingosine, and its phosphorylated form sphingosine-1- phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation (By similarity). Has a higher catalytic efficiency towards C12-ceramides versus other ceramides (By similarity). Also catalyzes the reverse reaction allowing the synthesis of ceramides from fatt [...] | Ceramide synthase 2. | 0.945 |
| ASAH1 | CERS3 | ENSMFAP00000045035 | ENSMFAP00000024408 | Acid ceramidase subunit alpha; Lysosomal ceramidase that hydrolyzes sphingolipid ceramides into sphingosine and free fatty acids at acidic pH (By similarity). Ceramides, sphingosine, and its phosphorylated form sphingosine-1- phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation (By similarity). Has a higher catalytic efficiency towards C12-ceramides versus other ceramides (By similarity). Also catalyzes the reverse reaction allowing the synthesis of ceramides from fatt [...] | Ceramide synthase 3. | 0.936 |
| ASAH1 | CERS4 | ENSMFAP00000045035 | ENSMFAP00000025887 | Acid ceramidase subunit alpha; Lysosomal ceramidase that hydrolyzes sphingolipid ceramides into sphingosine and free fatty acids at acidic pH (By similarity). Ceramides, sphingosine, and its phosphorylated form sphingosine-1- phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation (By similarity). Has a higher catalytic efficiency towards C12-ceramides versus other ceramides (By similarity). Also catalyzes the reverse reaction allowing the synthesis of ceramides from fatt [...] | Ceramide synthase 4. | 0.929 |
| ASAH1 | CERS6 | ENSMFAP00000045035 | ENSMFAP00000039986 | Acid ceramidase subunit alpha; Lysosomal ceramidase that hydrolyzes sphingolipid ceramides into sphingosine and free fatty acids at acidic pH (By similarity). Ceramides, sphingosine, and its phosphorylated form sphingosine-1- phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation (By similarity). Has a higher catalytic efficiency towards C12-ceramides versus other ceramides (By similarity). Also catalyzes the reverse reaction allowing the synthesis of ceramides from fatt [...] | Ceramide synthase 6. | 0.944 |
| ASAH1 | DEGS1 | ENSMFAP00000045035 | ENSMFAP00000002139 | Acid ceramidase subunit alpha; Lysosomal ceramidase that hydrolyzes sphingolipid ceramides into sphingosine and free fatty acids at acidic pH (By similarity). Ceramides, sphingosine, and its phosphorylated form sphingosine-1- phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation (By similarity). Has a higher catalytic efficiency towards C12-ceramides versus other ceramides (By similarity). Also catalyzes the reverse reaction allowing the synthesis of ceramides from fatt [...] | Delta 4-desaturase, sphingolipid 1. | 0.947 |
| ASAH1 | KDSR | ENSMFAP00000045035 | ENSMFAP00000009793 | Acid ceramidase subunit alpha; Lysosomal ceramidase that hydrolyzes sphingolipid ceramides into sphingosine and free fatty acids at acidic pH (By similarity). Ceramides, sphingosine, and its phosphorylated form sphingosine-1- phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation (By similarity). Has a higher catalytic efficiency towards C12-ceramides versus other ceramides (By similarity). Also catalyzes the reverse reaction allowing the synthesis of ceramides from fatt [...] | 3-ketodihydrosphingosine reductase; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.945 |
| ASAH1 | SGMS1 | ENSMFAP00000045035 | ENSMFAP00000005430 | Acid ceramidase subunit alpha; Lysosomal ceramidase that hydrolyzes sphingolipid ceramides into sphingosine and free fatty acids at acidic pH (By similarity). Ceramides, sphingosine, and its phosphorylated form sphingosine-1- phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation (By similarity). Has a higher catalytic efficiency towards C12-ceramides versus other ceramides (By similarity). Also catalyzes the reverse reaction allowing the synthesis of ceramides from fatt [...] | Sphingomyelin synthase 1. | 0.939 |
| ASAH1 | SMPD2 | ENSMFAP00000045035 | ENSMFAP00000020545 | Acid ceramidase subunit alpha; Lysosomal ceramidase that hydrolyzes sphingolipid ceramides into sphingosine and free fatty acids at acidic pH (By similarity). Ceramides, sphingosine, and its phosphorylated form sphingosine-1- phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation (By similarity). Has a higher catalytic efficiency towards C12-ceramides versus other ceramides (By similarity). Also catalyzes the reverse reaction allowing the synthesis of ceramides from fatt [...] | Sphingomyelin phosphodiesterase 2. | 0.805 |
| ASAH1 | SMPD3 | ENSMFAP00000045035 | ENSMFAP00000005595 | Acid ceramidase subunit alpha; Lysosomal ceramidase that hydrolyzes sphingolipid ceramides into sphingosine and free fatty acids at acidic pH (By similarity). Ceramides, sphingosine, and its phosphorylated form sphingosine-1- phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation (By similarity). Has a higher catalytic efficiency towards C12-ceramides versus other ceramides (By similarity). Also catalyzes the reverse reaction allowing the synthesis of ceramides from fatt [...] | Sphingomyelin phosphodiesterase 3. | 0.770 |
| CERS1 | ASAH1 | ENSMFAP00000027134 | ENSMFAP00000045035 | TLC domain-containing protein. | Acid ceramidase subunit alpha; Lysosomal ceramidase that hydrolyzes sphingolipid ceramides into sphingosine and free fatty acids at acidic pH (By similarity). Ceramides, sphingosine, and its phosphorylated form sphingosine-1- phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation (By similarity). Has a higher catalytic efficiency towards C12-ceramides versus other ceramides (By similarity). Also catalyzes the reverse reaction allowing the synthesis of ceramides from fatt [...] | 0.929 |
| CERS1 | CERS2 | ENSMFAP00000027134 | ENSMFAP00000038504 | TLC domain-containing protein. | Ceramide synthase 2. | 0.901 |
| CERS1 | CERS3 | ENSMFAP00000027134 | ENSMFAP00000024408 | TLC domain-containing protein. | Ceramide synthase 3. | 0.900 |
| CERS1 | CERS4 | ENSMFAP00000027134 | ENSMFAP00000025887 | TLC domain-containing protein. | Ceramide synthase 4. | 0.900 |
| CERS1 | CERS6 | ENSMFAP00000027134 | ENSMFAP00000039986 | TLC domain-containing protein. | Ceramide synthase 6. | 0.918 |
| CERS1 | DEGS1 | ENSMFAP00000027134 | ENSMFAP00000002139 | TLC domain-containing protein. | Delta 4-desaturase, sphingolipid 1. | 0.945 |
| CERS1 | KDSR | ENSMFAP00000027134 | ENSMFAP00000009793 | TLC domain-containing protein. | 3-ketodihydrosphingosine reductase; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.938 |
| CERS1 | SGMS1 | ENSMFAP00000027134 | ENSMFAP00000005430 | TLC domain-containing protein. | Sphingomyelin synthase 1. | 0.922 |
| CERS1 | SMPD2 | ENSMFAP00000027134 | ENSMFAP00000020545 | TLC domain-containing protein. | Sphingomyelin phosphodiesterase 2. | 0.736 |
| CERS1 | SMPD3 | ENSMFAP00000027134 | ENSMFAP00000005595 | TLC domain-containing protein. | Sphingomyelin phosphodiesterase 3. | 0.746 |
