Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
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[Homology]
Score
ARHGAP17Rho GTPase activating protein 17. (863 aa)    
Predicted Functional Partners:
AMOT
Angiomotin.
    
 0.984
ENSMFAP00000012835
Uncharacterized protein.
   
 0.949
CDC42
Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections (By similarity). Require [...]
   
 0.949
AMOTL1
Angiomotin like 1.
    
 0.943
AMOTL2
Angiomotin like 2.
    
 0.924
SH3KBP1
SH3 domain containing kinase binding protein 1.
    
 
 0.910
SH3BP1
Uncharacterized protein.
    
   0.903
TRIP10
Thyroid hormone receptor interactor 10.
    
 0.871
MPP5
Membrane palmitoylated protein 5; Belongs to the MAGUK family.
   
 
 0.866
ARHGAP44
Rho GTPase activating protein 44.
    
   0.809
Your Current Organism:
Macaca fascicularis
NCBI taxonomy Id: 9541
Other names: M. fascicularis, Macaca cynomolgus, Macaca irus, crab eating macaque, crab-eating macaque, cynomolgus macaque, cynomolgus monkey, cynomolgus monkeys, long-tailed macaque
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