Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
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[Homology]
Score
ERCC8ERCC excision repair 8, CSA ubiquitin ligase complex subunit. (396 aa)    
Predicted Functional Partners:
DDB1
Damage specific DNA binding protein 1.
    
 0.996
ERCC6
ERCC excision repair 6, chromatin remodeling factor.
    
 0.984
CUL4A
Cullin 4A; Belongs to the cullin family.
    
 0.981
CUL4B
Cullin 4B; Belongs to the cullin family.
    
 0.981
DDB2
Damage specific DNA binding protein 2.
    
0.980
UVSSA
UV stimulated scaffold protein A.
    
 0.958
RBX1
RING-box protein 1.
    
 0.955
COP1
COP1 E3 ubiquitin ligase.
    
 0.953
COPS2
Brain cDNA, clone: QnpA-16974, similar to human thyroid receptor interacting protein 15 (TRIP15).
    
 0.943
ENSMFAP00000045746
Zf-rbx1 domain-containing protein.
    
 0.932
Your Current Organism:
Macaca fascicularis
NCBI taxonomy Id: 9541
Other names: M. fascicularis, Macaca cynomolgus, Macaca irus, crab eating macaque, crab-eating macaque, cynomolgus macaque, cynomolgus monkey, cynomolgus monkeys, long-tailed macaque
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