STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CDC25BCell division cycle 25B. (580 aa)    
Predicted Functional Partners:
CHEK1
Checkpoint kinase 1; Belongs to the protein kinase superfamily.
   
 0.919
YWHAB
14-3-3 protein beta/alpha, N-terminally processed; Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negative regulator of osteogenesis. Blocks the nuclear translocation of the phosphorylated form (by AKT1) of SRPK2 and antagonizes its stimulatory effect on cyclin D1 expression resulting in blockage of neuronal apoptosis elicited by [...]
    
 0.883
CHEK2
Checkpoint kinase 2.
   
 0.837
CCNA2
Cyclin A2; Belongs to the cyclin family.
   
 0.827
CDK2
Cyclin dependent kinase 2; Belongs to the protein kinase superfamily.
   
 0.823
CCNA1
Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.
   
 0.821
PLK1
Serine/threonine-protein kinase PLK.
   
 0.815
LOC102142638
Protein kinase domain-containing protein.
   
 0.806
CDK1
Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.
   
 0.806
CCNE2
Cyclin E2; Belongs to the cyclin family.
   
 0.788
Your Current Organism:
Macaca fascicularis
NCBI taxonomy Id: 9541
Other names: M. fascicularis, Macaca cynomolgus, Macaca irus, crab eating macaque, crab-eating macaque, cynomolgus macaque, cynomolgus monkey, cynomolgus monkeys, long-tailed macaque
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.