| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CACUL1 | CAND1 | ENSMFAP00000004352 | ENSMFAP00000025886 | CDK2 associated cullin domain 1; Belongs to the cullin family. | Cullin associated and neddylation dissociated 1. | 0.761 |
| CACUL1 | COPS4 | ENSMFAP00000004352 | ENSMFAP00000027787 | CDK2 associated cullin domain 1; Belongs to the cullin family. | COP9 signalosome complex subunit 4; Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes (By similarity). The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2 (By similarity). Also involved in the deneddylation of non-cullin subunits such as STON2 (By similarity). The complex is also involved in phosphorylation of p53 [...] | 0.768 |
| CACUL1 | ENSMFAP00000030335 | ENSMFAP00000004352 | ENSMFAP00000030335 | CDK2 associated cullin domain 1; Belongs to the cullin family. | Uncharacterized protein; Belongs to the SKP1 family. | 0.764 |
| CACUL1 | ENSMFAP00000031351 | ENSMFAP00000004352 | ENSMFAP00000031351 | CDK2 associated cullin domain 1; Belongs to the cullin family. | Uncharacterized protein; Belongs to the SKP1 family. | 0.764 |
| CACUL1 | FBXL19 | ENSMFAP00000004352 | ENSMFAP00000032938 | CDK2 associated cullin domain 1; Belongs to the cullin family. | F-box and leucine rich repeat protein 19. | 0.797 |
| CACUL1 | KDM2A | ENSMFAP00000004352 | ENSMFAP00000017410 | CDK2 associated cullin domain 1; Belongs to the cullin family. | Lysine demethylase 2A. | 0.797 |
| CACUL1 | KDM2B | ENSMFAP00000004352 | ENSMFAP00000006664 | CDK2 associated cullin domain 1; Belongs to the cullin family. | Lysine demethylase 2B. | 0.797 |
| CACUL1 | SKP1 | ENSMFAP00000004352 | ENSMFAP00000043769 | CDK2 associated cullin domain 1; Belongs to the cullin family. | S-phase kinase-associated protein 1; Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC [...] | 0.764 |
| CACUL1 | SKP2 | ENSMFAP00000004352 | ENSMFAP00000014684 | CDK2 associated cullin domain 1; Belongs to the cullin family. | S-phase kinase associated protein 2. | 0.794 |
| CACUL1 | UBXN7 | ENSMFAP00000004352 | ENSMFAP00000032174 | CDK2 associated cullin domain 1; Belongs to the cullin family. | UBX domain protein 7. | 0.950 |
| CAND1 | CACUL1 | ENSMFAP00000025886 | ENSMFAP00000004352 | Cullin associated and neddylation dissociated 1. | CDK2 associated cullin domain 1; Belongs to the cullin family. | 0.761 |
| CAND1 | ENSMFAP00000030335 | ENSMFAP00000025886 | ENSMFAP00000030335 | Cullin associated and neddylation dissociated 1. | Uncharacterized protein; Belongs to the SKP1 family. | 0.791 |
| CAND1 | ENSMFAP00000031351 | ENSMFAP00000025886 | ENSMFAP00000031351 | Cullin associated and neddylation dissociated 1. | Uncharacterized protein; Belongs to the SKP1 family. | 0.791 |
| CAND1 | FBXL19 | ENSMFAP00000025886 | ENSMFAP00000032938 | Cullin associated and neddylation dissociated 1. | F-box and leucine rich repeat protein 19. | 0.612 |
| CAND1 | KDM2A | ENSMFAP00000025886 | ENSMFAP00000017410 | Cullin associated and neddylation dissociated 1. | Lysine demethylase 2A. | 0.613 |
| CAND1 | KDM2B | ENSMFAP00000025886 | ENSMFAP00000006664 | Cullin associated and neddylation dissociated 1. | Lysine demethylase 2B. | 0.613 |
| CAND1 | SKP1 | ENSMFAP00000025886 | ENSMFAP00000043769 | Cullin associated and neddylation dissociated 1. | S-phase kinase-associated protein 1; Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC [...] | 0.837 |
| CAND1 | SKP2 | ENSMFAP00000025886 | ENSMFAP00000014684 | Cullin associated and neddylation dissociated 1. | S-phase kinase associated protein 2. | 0.886 |
| COPS4 | CACUL1 | ENSMFAP00000027787 | ENSMFAP00000004352 | COP9 signalosome complex subunit 4; Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes (By similarity). The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2 (By similarity). Also involved in the deneddylation of non-cullin subunits such as STON2 (By similarity). The complex is also involved in phosphorylation of p53 [...] | CDK2 associated cullin domain 1; Belongs to the cullin family. | 0.768 |
| COPS4 | ENSMFAP00000030335 | ENSMFAP00000027787 | ENSMFAP00000030335 | COP9 signalosome complex subunit 4; Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes (By similarity). The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2 (By similarity). Also involved in the deneddylation of non-cullin subunits such as STON2 (By similarity). The complex is also involved in phosphorylation of p53 [...] | Uncharacterized protein; Belongs to the SKP1 family. | 0.474 |
