node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABCA1 | APOA1 | ENSMFAP00000005316 | ENSMFAP00000037249 | ATP binding cassette subfamily A member 1. | Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility. | 0.934 |
ABCA1 | APOA2 | ENSMFAP00000005316 | ENSMFAP00000015741 | ATP binding cassette subfamily A member 1. | Truncated apolipoprotein A-II; May stabilize HDL (high density lipoprotein) structure by its association with lipids, and affect the HDL metabolism; Belongs to the apolipoprotein A2 family. | 0.798 |
ABCA1 | APOB | ENSMFAP00000005316 | ENSMFAP00000001511 | ATP binding cassette subfamily A member 1. | Apolipoprotein B. | 0.867 |
ABCA1 | APOE | ENSMFAP00000005316 | ENSMFAP00000029949 | ATP binding cassette subfamily A member 1. | Apolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...] | 0.868 |
ABCA1 | CETP | ENSMFAP00000005316 | ENSMFAP00000039968 | ATP binding cassette subfamily A member 1. | Cholesteryl ester transfer protein; Involved in the transfer of neutral lipids, including cholesteryl ester and triglyceride, among lipoprotein particles. Allows the net movement of cholesteryl ester from high density lipoproteins/HDL to triglyceride-rich very low density lipoproteins/VLDL, and the equimolar transport of triglyceride from VLDL to HDL. Regulates the reverse cholesterol transport, by which excess cholesterol is removed from peripheral tissues and returned to the liver for elimination (By similarity). Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family. | 0.800 |
ABCA1 | FGA | ENSMFAP00000005316 | ENSMFAP00000027818 | ATP binding cassette subfamily A member 1. | Fibrinogen alpha chain. | 0.786 |
ABCA1 | FGB | ENSMFAP00000005316 | ENSMFAP00000027485 | ATP binding cassette subfamily A member 1. | Fibrinogen beta chain. | 0.782 |
ABCA1 | LCAT | ENSMFAP00000005316 | ENSMFAP00000035267 | ATP binding cassette subfamily A member 1. | Lecithin-cholesterol acyltransferase. | 0.765 |
ABCA1 | NR1H2 | ENSMFAP00000005316 | ENSMFAP00000045696 | ATP binding cassette subfamily A member 1. | Nuclear receptor subfamily 1 group H member 2. | 0.834 |
ABCA1 | NR1H3 | ENSMFAP00000005316 | ENSMFAP00000004709 | ATP binding cassette subfamily A member 1. | Nuclear receptor subfamily 1 group H member 3. | 0.813 |
APOA1 | ABCA1 | ENSMFAP00000037249 | ENSMFAP00000005316 | Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility. | ATP binding cassette subfamily A member 1. | 0.934 |
APOA1 | APOA2 | ENSMFAP00000037249 | ENSMFAP00000015741 | Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility. | Truncated apolipoprotein A-II; May stabilize HDL (high density lipoprotein) structure by its association with lipids, and affect the HDL metabolism; Belongs to the apolipoprotein A2 family. | 0.869 |
APOA1 | APOB | ENSMFAP00000037249 | ENSMFAP00000001511 | Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility. | Apolipoprotein B. | 0.861 |
APOA1 | APOE | ENSMFAP00000037249 | ENSMFAP00000029949 | Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility. | Apolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...] | 0.898 |
APOA1 | CETP | ENSMFAP00000037249 | ENSMFAP00000039968 | Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility. | Cholesteryl ester transfer protein; Involved in the transfer of neutral lipids, including cholesteryl ester and triglyceride, among lipoprotein particles. Allows the net movement of cholesteryl ester from high density lipoproteins/HDL to triglyceride-rich very low density lipoproteins/VLDL, and the equimolar transport of triglyceride from VLDL to HDL. Regulates the reverse cholesterol transport, by which excess cholesterol is removed from peripheral tissues and returned to the liver for elimination (By similarity). Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family. | 0.677 |
APOA1 | LCAT | ENSMFAP00000037249 | ENSMFAP00000035267 | Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility. | Lecithin-cholesterol acyltransferase. | 0.961 |
APOA2 | ABCA1 | ENSMFAP00000015741 | ENSMFAP00000005316 | Truncated apolipoprotein A-II; May stabilize HDL (high density lipoprotein) structure by its association with lipids, and affect the HDL metabolism; Belongs to the apolipoprotein A2 family. | ATP binding cassette subfamily A member 1. | 0.798 |
APOA2 | APOA1 | ENSMFAP00000015741 | ENSMFAP00000037249 | Truncated apolipoprotein A-II; May stabilize HDL (high density lipoprotein) structure by its association with lipids, and affect the HDL metabolism; Belongs to the apolipoprotein A2 family. | Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility. | 0.869 |
APOA2 | APOB | ENSMFAP00000015741 | ENSMFAP00000001511 | Truncated apolipoprotein A-II; May stabilize HDL (high density lipoprotein) structure by its association with lipids, and affect the HDL metabolism; Belongs to the apolipoprotein A2 family. | Apolipoprotein B. | 0.979 |
APOA2 | APOE | ENSMFAP00000015741 | ENSMFAP00000029949 | Truncated apolipoprotein A-II; May stabilize HDL (high density lipoprotein) structure by its association with lipids, and affect the HDL metabolism; Belongs to the apolipoprotein A2 family. | Apolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...] | 0.970 |