| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CYP1A2 | CYP26A1 | ENSMFAP00000008453 | ENSMFAP00000040960 | Cytochrome P450 1A2; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E [...] | Cytochrome P450 family 26 subfamily A member 1; Belongs to the cytochrome P450 family. | 0.953 |
| CYP1A2 | CYP26B1 | ENSMFAP00000008453 | ENSMFAP00000041980 | Cytochrome P450 1A2; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E [...] | Cytochrome P450 family 26 subfamily B member 1; Belongs to the cytochrome P450 family. | 0.945 |
| CYP1A2 | CYP26C1 | ENSMFAP00000008453 | ENSMFAP00000042430 | Cytochrome P450 1A2; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E [...] | Cytochrome P450 family 26 subfamily C member 1; Belongs to the cytochrome P450 family. | 0.928 |
| CYP1A2 | CYP2A24 | ENSMFAP00000008453 | ENSMFAP00000006571 | Cytochrome P450 1A2; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E [...] | Uncharacterized protein; Belongs to the cytochrome P450 family. | 0.940 |
| CYP1A2 | CYP2D17 | ENSMFAP00000008453 | ENSMFAP00000021296 | Cytochrome P450 1A2; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E [...] | Cytochrome P450 2D17. | 0.463 |
| CYP1A2 | CYP3A4 | ENSMFAP00000008453 | ENSMFAP00000039737 | Cytochrome P450 1A2; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E [...] | Cytochrome P450 3A8; Catalyzes nifedipine and nilvadipine oxidations. | 0.966 |
| CYP1A2 | CYP3A5 | ENSMFAP00000008453 | ENSMFAP00000033557 | Cytochrome P450 1A2; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E [...] | Cytochrome P450 family 3 subfamily A member 5. | 0.960 |
| CYP1A2 | CYP3A7 | ENSMFAP00000008453 | ENSMFAP00000021639 | Cytochrome P450 1A2; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E [...] | Uncharacterized protein. | 0.957 |
| CYP1A2 | GSTM5 | ENSMFAP00000008453 | ENSMFAP00000030336 | Cytochrome P450 1A2; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E [...] | Glutathione S-transferase. | 0.915 |
| CYP26A1 | CYP1A2 | ENSMFAP00000040960 | ENSMFAP00000008453 | Cytochrome P450 family 26 subfamily A member 1; Belongs to the cytochrome P450 family. | Cytochrome P450 1A2; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E [...] | 0.953 |
| CYP26A1 | CYP26B1 | ENSMFAP00000040960 | ENSMFAP00000041980 | Cytochrome P450 family 26 subfamily A member 1; Belongs to the cytochrome P450 family. | Cytochrome P450 family 26 subfamily B member 1; Belongs to the cytochrome P450 family. | 0.912 |
| CYP26A1 | CYP26C1 | ENSMFAP00000040960 | ENSMFAP00000042430 | Cytochrome P450 family 26 subfamily A member 1; Belongs to the cytochrome P450 family. | Cytochrome P450 family 26 subfamily C member 1; Belongs to the cytochrome P450 family. | 0.916 |
| CYP26A1 | CYP2A24 | ENSMFAP00000040960 | ENSMFAP00000006571 | Cytochrome P450 family 26 subfamily A member 1; Belongs to the cytochrome P450 family. | Uncharacterized protein; Belongs to the cytochrome P450 family. | 0.932 |
| CYP26A1 | CYP3A4 | ENSMFAP00000040960 | ENSMFAP00000039737 | Cytochrome P450 family 26 subfamily A member 1; Belongs to the cytochrome P450 family. | Cytochrome P450 3A8; Catalyzes nifedipine and nilvadipine oxidations. | 0.929 |
| CYP26A1 | CYP3A5 | ENSMFAP00000040960 | ENSMFAP00000033557 | Cytochrome P450 family 26 subfamily A member 1; Belongs to the cytochrome P450 family. | Cytochrome P450 family 3 subfamily A member 5. | 0.928 |
| CYP26A1 | CYP3A7 | ENSMFAP00000040960 | ENSMFAP00000021639 | Cytochrome P450 family 26 subfamily A member 1; Belongs to the cytochrome P450 family. | Uncharacterized protein. | 0.928 |
| CYP26B1 | CYP1A2 | ENSMFAP00000041980 | ENSMFAP00000008453 | Cytochrome P450 family 26 subfamily B member 1; Belongs to the cytochrome P450 family. | Cytochrome P450 1A2; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E [...] | 0.945 |
| CYP26B1 | CYP26A1 | ENSMFAP00000041980 | ENSMFAP00000040960 | Cytochrome P450 family 26 subfamily B member 1; Belongs to the cytochrome P450 family. | Cytochrome P450 family 26 subfamily A member 1; Belongs to the cytochrome P450 family. | 0.912 |
| CYP26B1 | CYP26C1 | ENSMFAP00000041980 | ENSMFAP00000042430 | Cytochrome P450 family 26 subfamily B member 1; Belongs to the cytochrome P450 family. | Cytochrome P450 family 26 subfamily C member 1; Belongs to the cytochrome P450 family. | 0.916 |
| CYP26B1 | CYP2A24 | ENSMFAP00000041980 | ENSMFAP00000006571 | Cytochrome P450 family 26 subfamily B member 1; Belongs to the cytochrome P450 family. | Uncharacterized protein; Belongs to the cytochrome P450 family. | 0.934 |
