node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACD | POT1 | ENSMFAP00000037639 | ENSMFAP00000003291 | ACD shelterin complex subunit and telomerase recruitment factor. | Protection of telomeres protein 1; Component of the telomerase ribonucleoprotein (RNP) complex that is essential for the replication of chromosome termini. Is a component of the double-stranded telomeric DNA-binding TRF1 complex which is involved in the regulation of telomere length by cis- inhibition of telomerase. Also acts as a single-stranded telomeric DNA- binding protein and thus may act as a downstream effector of the TRF1 complex and may transduce information about telomere maintenance and/or length to the telomere terminus. Component of the shelterin complex (telosome) that is [...] | 0.994 |
ACD | TERF1 | ENSMFAP00000037639 | ENSMFAP00000045953 | ACD shelterin complex subunit and telomerase recruitment factor. | Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. | 0.977 |
ACD | TERF2 | ENSMFAP00000037639 | ENSMFAP00000025179 | ACD shelterin complex subunit and telomerase recruitment factor. | Telomeric repeat binding factor 2. | 0.984 |
ACD | TERF2IP | ENSMFAP00000037639 | ENSMFAP00000008076 | ACD shelterin complex subunit and telomerase recruitment factor. | Telomeric repeat-binding factor 2-interacting protein 1; Acts both as a regulator of telomere function and as a transcription regulator. Involved in the regulation of telomere length and protection as a component of the shelterin complex (telosome). In contrast to other components of the shelterin complex, it is dispensible for telomere capping and does not participate in the protection of telomeres against non-homologous end-joining (NHEJ)- mediated repair. Instead, it is required to negatively regulate telomere recombination and is essential for repressing homology- directed repair ( [...] | 0.964 |
ACD | TINF2 | ENSMFAP00000037639 | ENSMFAP00000018285 | ACD shelterin complex subunit and telomerase recruitment factor. | TERF1 interacting nuclear factor 2. | 0.994 |
ADAT1 | TERF2IP | ENSMFAP00000012891 | ENSMFAP00000008076 | tRNA-specific adenosine deaminase 1; Specifically deaminates adenosine-37 to inosine in tRNA-Ala. | Telomeric repeat-binding factor 2-interacting protein 1; Acts both as a regulator of telomere function and as a transcription regulator. Involved in the regulation of telomere length and protection as a component of the shelterin complex (telosome). In contrast to other components of the shelterin complex, it is dispensible for telomere capping and does not participate in the protection of telomeres against non-homologous end-joining (NHEJ)- mediated repair. Instead, it is required to negatively regulate telomere recombination and is essential for repressing homology- directed repair ( [...] | 0.720 |
ENSMFAP00000044831 | NBN | ENSMFAP00000044831 | ENSMFAP00000015275 | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. | Nibrin. | 0.971 |
ENSMFAP00000044831 | POT1 | ENSMFAP00000044831 | ENSMFAP00000003291 | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. | Protection of telomeres protein 1; Component of the telomerase ribonucleoprotein (RNP) complex that is essential for the replication of chromosome termini. Is a component of the double-stranded telomeric DNA-binding TRF1 complex which is involved in the regulation of telomere length by cis- inhibition of telomerase. Also acts as a single-stranded telomeric DNA- binding protein and thus may act as a downstream effector of the TRF1 complex and may transduce information about telomere maintenance and/or length to the telomere terminus. Component of the shelterin complex (telosome) that is [...] | 0.446 |
ENSMFAP00000044831 | TERF1 | ENSMFAP00000044831 | ENSMFAP00000045953 | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. | Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. | 0.442 |
ENSMFAP00000044831 | TERF2 | ENSMFAP00000044831 | ENSMFAP00000025179 | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. | Telomeric repeat binding factor 2. | 0.703 |
ENSMFAP00000044831 | TERF2IP | ENSMFAP00000044831 | ENSMFAP00000008076 | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. | Telomeric repeat-binding factor 2-interacting protein 1; Acts both as a regulator of telomere function and as a transcription regulator. Involved in the regulation of telomere length and protection as a component of the shelterin complex (telosome). In contrast to other components of the shelterin complex, it is dispensible for telomere capping and does not participate in the protection of telomeres against non-homologous end-joining (NHEJ)- mediated repair. Instead, it is required to negatively regulate telomere recombination and is essential for repressing homology- directed repair ( [...] | 0.704 |
ENSMFAP00000044831 | TINF2 | ENSMFAP00000044831 | ENSMFAP00000018285 | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. | TERF1 interacting nuclear factor 2. | 0.434 |
MRE11 | NBN | ENSMFAP00000043992 | ENSMFAP00000015275 | Double-strand break repair protein MRE11; Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11. RAD50 may be required to bind DNA ends and hold them in close proximity. This could facilitate searches for short or long regions of sequence homology in the recombining DNA templates, and may also stimulate the activity of DNA ligases and/or restr [...] | Nibrin. | 0.994 |
MRE11 | POT1 | ENSMFAP00000043992 | ENSMFAP00000003291 | Double-strand break repair protein MRE11; Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11. RAD50 may be required to bind DNA ends and hold them in close proximity. This could facilitate searches for short or long regions of sequence homology in the recombining DNA templates, and may also stimulate the activity of DNA ligases and/or restr [...] | Protection of telomeres protein 1; Component of the telomerase ribonucleoprotein (RNP) complex that is essential for the replication of chromosome termini. Is a component of the double-stranded telomeric DNA-binding TRF1 complex which is involved in the regulation of telomere length by cis- inhibition of telomerase. Also acts as a single-stranded telomeric DNA- binding protein and thus may act as a downstream effector of the TRF1 complex and may transduce information about telomere maintenance and/or length to the telomere terminus. Component of the shelterin complex (telosome) that is [...] | 0.446 |
MRE11 | TERF1 | ENSMFAP00000043992 | ENSMFAP00000045953 | Double-strand break repair protein MRE11; Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11. RAD50 may be required to bind DNA ends and hold them in close proximity. This could facilitate searches for short or long regions of sequence homology in the recombining DNA templates, and may also stimulate the activity of DNA ligases and/or restr [...] | Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. | 0.442 |
MRE11 | TERF2 | ENSMFAP00000043992 | ENSMFAP00000025179 | Double-strand break repair protein MRE11; Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11. RAD50 may be required to bind DNA ends and hold them in close proximity. This could facilitate searches for short or long regions of sequence homology in the recombining DNA templates, and may also stimulate the activity of DNA ligases and/or restr [...] | Telomeric repeat binding factor 2. | 0.703 |
MRE11 | TERF2IP | ENSMFAP00000043992 | ENSMFAP00000008076 | Double-strand break repair protein MRE11; Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11. RAD50 may be required to bind DNA ends and hold them in close proximity. This could facilitate searches for short or long regions of sequence homology in the recombining DNA templates, and may also stimulate the activity of DNA ligases and/or restr [...] | Telomeric repeat-binding factor 2-interacting protein 1; Acts both as a regulator of telomere function and as a transcription regulator. Involved in the regulation of telomere length and protection as a component of the shelterin complex (telosome). In contrast to other components of the shelterin complex, it is dispensible for telomere capping and does not participate in the protection of telomeres against non-homologous end-joining (NHEJ)- mediated repair. Instead, it is required to negatively regulate telomere recombination and is essential for repressing homology- directed repair ( [...] | 0.704 |
MRE11 | TINF2 | ENSMFAP00000043992 | ENSMFAP00000018285 | Double-strand break repair protein MRE11; Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11. RAD50 may be required to bind DNA ends and hold them in close proximity. This could facilitate searches for short or long regions of sequence homology in the recombining DNA templates, and may also stimulate the activity of DNA ligases and/or restr [...] | TERF1 interacting nuclear factor 2. | 0.434 |
NBN | ENSMFAP00000044831 | ENSMFAP00000015275 | ENSMFAP00000044831 | Nibrin. | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. | 0.971 |
NBN | MRE11 | ENSMFAP00000015275 | ENSMFAP00000043992 | Nibrin. | Double-strand break repair protein MRE11; Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11. RAD50 may be required to bind DNA ends and hold them in close proximity. This could facilitate searches for short or long regions of sequence homology in the recombining DNA templates, and may also stimulate the activity of DNA ligases and/or restr [...] | 0.994 |