Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
SPG7SPG7 matrix AAA peptidase subunit, paraplegin. (794 aa)    
Predicted Functional Partners:
MAIP1
Matrix AAA peptidase interacting protein 1.
    
 0.924
CSPG5
Uncharacterized protein.
      
 0.912
AFG3L2
AFG3 like matrix AAA peptidase subunit 2.
  
 
0.871
SMDT1
Single-pass membrane protein with aspartate rich tail 1.
     
 0.853
YME1L1
AAA domain-containing protein.
   
 0.821
DRAM1
DNA damage regulated autophagy modulator 1.
      
 0.813
COBL
Cordon-bleu WH2 repeat protein.
      
 0.778
PMPCA
Peptidase, mitochondrial processing alpha subunit; Belongs to the peptidase M16 family.
  
 0.769
MICU1
Calcium uptake protein 1, mitochondrial; Key regulator of mitochondrial calcium uniporter (MCU) that senses calcium level via its EF-hand domains. MICU1 and MICU2 form a disulfide-linked heterodimer that stimulates and inhibits MCU activity, depending on the concentration of calcium. MICU1 acts both as an activator or inhibitor of mitochondrial calcium uptake. Acts as a gatekeeper of MCU at low concentration of calcium, preventing channel opening. Enhances MCU opening at high calcium concentration, allowing a rapid response of mitochondria to calcium signals generated in the cytoplasm. [...]
     
 0.766
FLVCR2
Feline leukemia virus subgroup C cellular receptor family member 2.
      
 0.765
Your Current Organism:
Macaca fascicularis
NCBI taxonomy Id: 9541
Other names: M. fascicularis, Macaca cynomolgus, Macaca irus, crab eating macaque, crab-eating macaque, cynomolgus macaque, cynomolgus monkey, cynomolgus monkeys, long-tailed macaque
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