Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
PDE4APhosphodiesterase. (832 aa)    
Predicted Functional Partners:
PRKACB
Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily.
   
 0.924
ADK
Adenosine kinase.
     
 0.920
AK3
GTP:AMP phosphotransferase AK3, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities.
     
 0.910
ADSL
Adenylosuccinate lyase; Catalyzes two non-sequential steps in de novo AMP synthesis: converts (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate (SAICAR) to fumarate plus 5-amino-1-(5-phospho-D- ribosyl)imidazole-4-carboxamide, and thereby also contributes to de novo IMP synthesis, and converts succinyladenosine monophosphate (SAMP) to AMP and fumarate; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
     
 0.910
ENPP3
Ectonucleotide pyrophosphatase/phosphodiesterase 3.
    
 0.909
ENPP1
Ectonucleotide pyrophosphatase/phosphodiesterase 1.
    
 0.909
APRT
Adenine phosphoribosyltransferase.
     
 0.907
PRKACA
Protein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily.
   
 0.887
PRKACG
Protein kinase cAMP-activated catalytic subunit gamma; Belongs to the protein kinase superfamily.
   
 0.887
CAMK2D
Protein kinase domain-containing protein.
   
 0.833
Your Current Organism:
Macaca fascicularis
NCBI taxonomy Id: 9541
Other names: M. fascicularis, Macaca cynomolgus, Macaca irus, crab eating macaque, crab-eating macaque, cynomolgus macaque, cynomolgus monkey, cynomolgus monkeys, long-tailed macaque
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