Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
ENSMFAP0000001001814_3_3 domain-containing protein; Belongs to the 14-3-3 family. (208 aa)    
Predicted Functional Partners:
YWHAB
14-3-3 protein beta/alpha, N-terminally processed; Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negative regulator of osteogenesis. Blocks the nuclear translocation of the phosphorylated form (by AKT1) of SRPK2 and antagonizes its stimulatory effect on cyclin D1 expression resulting in blockage of neuronal apoptosis elicited by [...]
   
  0.942
YWHAG
Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma; Belongs to the 14-3-3 family.
   
  0.942
YWHAH
14_3_3 domain-containing protein; Belongs to the 14-3-3 family.
   
  0.941
SFN
Stratifin; Belongs to the 14-3-3 family.
   
  0.915
ENSMFAP00000040719
14_3_3 domain-containing protein; Belongs to the 14-3-3 family.
   
 0.886
YWHAE
14_3_3 domain-containing protein; Belongs to the 14-3-3 family.
   
 0.886
YWHAZ
Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta; Belongs to the 14-3-3 family.
   
 0.884
ENSMFAP00000041691
14_3_3 domain-containing protein; Belongs to the 14-3-3 family.
   
 0.884
BRAF
B-Raf proto-oncogene, serine/threonine kinase.
    
 0.777
RAF1
Raf-1 proto-oncogene, serine/threonine kinase.
    
 0.777
Your Current Organism:
Macaca fascicularis
NCBI taxonomy Id: 9541
Other names: M. fascicularis, Macaca cynomolgus, Macaca irus, crab eating macaque, crab-eating macaque, cynomolgus macaque, cynomolgus monkey, cynomolgus monkeys, long-tailed macaque
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