Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
H1-5Histone cluster 1 H1 family member b. (226 aa)    
Predicted Functional Partners:
CDK2
Cyclin dependent kinase 2; Belongs to the protein kinase superfamily.
   
 0.915
LOC102142638
Protein kinase domain-containing protein.
   
 0.811
CDK1
Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.
   
 0.811
CCNE1
Cyclin E1; Belongs to the cyclin family.
    
 
 0.805
H2AC20
Histone H2A; Belongs to the histone H2A family.
   
 0.792
HIST2H2BE
Histone H2B; Belongs to the histone H2B family.
   
 0.758
H2BC11
Histone H2B type 1-K; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
   
 0.748
ENSMFAP00000014622
Histone H2B; Belongs to the histone H2B family.
   
 0.748
H2BC3
Histone H2B; Belongs to the histone H2B family.
   
 0.717
H1-8
H1 histone family member O oocyte specific.
   
 0.702
Your Current Organism:
Macaca fascicularis
NCBI taxonomy Id: 9541
Other names: M. fascicularis, Macaca cynomolgus, Macaca irus, crab eating macaque, crab-eating macaque, cynomolgus macaque, cynomolgus monkey, cynomolgus monkeys, long-tailed macaque
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