| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CD4 | CD74 | ENSMFAP00000041028 | ENSMFAP00000007939 | T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...] | CD74 molecule. | 0.720 |
| CD4 | DQB1 | ENSMFAP00000041028 | ENSMFAP00000010053 | T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...] | Ig-like domain-containing protein. | 0.932 |
| CD4 | HLA-DOA | ENSMFAP00000041028 | ENSMFAP00000042622 | T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...] | Major histocompatibility complex, class II, DO alpha; Belongs to the MHC class II family. | 0.930 |
| CD4 | HLA-DPA1 | ENSMFAP00000041028 | ENSMFAP00000001597 | T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...] | Major histocompatibility complex, class II, DP alpha 1; Belongs to the MHC class II family. | 0.924 |
| CD4 | HLA-DRA | ENSMFAP00000041028 | ENSMFAP00000018174 | T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...] | Major histocompatibility complex, class II, DR alpha; Belongs to the MHC class II family. | 0.956 |
| CD4 | HLA-DRB5 | ENSMFAP00000041028 | ENSMFAP00000008242 | T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...] | Ig-like domain-containing protein. | 0.926 |
| CD4 | INS | ENSMFAP00000041028 | ENSMFAP00000009056 | T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...] | Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | 0.796 |
| CD4 | LOC102140649 | ENSMFAP00000041028 | ENSMFAP00000035111 | T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...] | Ig-like domain-containing protein. | 0.909 |
| CD74 | CD4 | ENSMFAP00000007939 | ENSMFAP00000041028 | CD74 molecule. | T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...] | 0.720 |
| CD74 | DQB1 | ENSMFAP00000007939 | ENSMFAP00000010053 | CD74 molecule. | Ig-like domain-containing protein. | 0.993 |
| CD74 | HLA-DOA | ENSMFAP00000007939 | ENSMFAP00000042622 | CD74 molecule. | Major histocompatibility complex, class II, DO alpha; Belongs to the MHC class II family. | 0.972 |
| CD74 | HLA-DPA1 | ENSMFAP00000007939 | ENSMFAP00000001597 | CD74 molecule. | Major histocompatibility complex, class II, DP alpha 1; Belongs to the MHC class II family. | 0.980 |
| CD74 | HLA-DRA | ENSMFAP00000007939 | ENSMFAP00000018174 | CD74 molecule. | Major histocompatibility complex, class II, DR alpha; Belongs to the MHC class II family. | 0.998 |
| CD74 | HLA-DRB5 | ENSMFAP00000007939 | ENSMFAP00000008242 | CD74 molecule. | Ig-like domain-containing protein. | 0.994 |
| CD74 | LOC102140649 | ENSMFAP00000007939 | ENSMFAP00000035111 | CD74 molecule. | Ig-like domain-containing protein. | 0.977 |
| DQB1 | CD4 | ENSMFAP00000010053 | ENSMFAP00000041028 | Ig-like domain-containing protein. | T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...] | 0.932 |
| DQB1 | CD74 | ENSMFAP00000010053 | ENSMFAP00000007939 | Ig-like domain-containing protein. | CD74 molecule. | 0.993 |
| DQB1 | HCRT | ENSMFAP00000010053 | ENSMFAP00000041180 | Ig-like domain-containing protein. | Orexin; Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions. A broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal balance and the regulation of body fluids, is also suggested. Belongs to the orexin family. | 0.889 |
| DQB1 | HLA-DOA | ENSMFAP00000010053 | ENSMFAP00000042622 | Ig-like domain-containing protein. | Major histocompatibility complex, class II, DO alpha; Belongs to the MHC class II family. | 0.905 |
| DQB1 | HLA-DPA1 | ENSMFAP00000010053 | ENSMFAP00000001597 | Ig-like domain-containing protein. | Major histocompatibility complex, class II, DP alpha 1; Belongs to the MHC class II family. | 0.892 |
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