Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Co-occurrence
Co-expression
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[Homology]
Score
SPRY1Sprouty RTK signaling antagonist 1. (319 aa)    
Predicted Functional Partners:
CBL
Cbl proto-oncogene.
    
 0.957
CBLB
Cbl proto-oncogene B.
    
 0.846
ETV5
Testis cDNA, clone: QtsA-18044, similar to human ets variant gene 5 (ets-related molecule) (ETV5).
      
 0.769
SPRY2
Protein sprouty homolog 2; May function as an antagonist of fibroblast growth factor (FGF) pathways and may negatively modulate respiratory organogenesis.
   
  0.754
CNPY1
Canopy FGF signaling regulator 1.
      
 0.718
GRB2
Growth factor receptor-binding protein 2.
    
 
 0.709
MDFI
MyoD family inhibitor.
    
 
 0.708
HOXA1
Homeobox A1.
    
 
 0.687
AREG
Amphiregulin.
     
  0.650
HBEGF
Heparin binding EGF like growth factor.
     
  0.643
Your Current Organism:
Macaca fascicularis
NCBI taxonomy Id: 9541
Other names: M. fascicularis, Macaca cynomolgus, Macaca irus, crab eating macaque, crab-eating macaque, cynomolgus macaque, cynomolgus monkey, cynomolgus monkeys, long-tailed macaque
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