Nodes:
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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experimentally determined
co-expression
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gene neighborhood
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gene fusions
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[Homology]
Score
LOC102119743C-C motif chemokine. (92 aa)    
Predicted Functional Partners:
CCR5
C-C chemokine receptor type 5; Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation (By similarity).
   
 0.954
LOC102118223
C-C motif chemokine.
  
0.953
CCL3
C-C motif chemokine.
  
  
 
0.900
CCR4
C-C motif chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family.
   
 0.887
CCR2
C-C motif chemokine receptor 2; Belongs to the G-protein coupled receptor 1 family.
   
 0.839
CCR3
C-C chemokine receptor type 3; Receptor for C-C type chemokine. Binds and responds to a variety of chemokines, including CCL11, CCL26, CCL7, CCL13, RANTES(CCL5) and CCL15. Subsequently transduces a signal by increasing the intracellular calcium ions level. In addition acts as a possible functional receptor for NARS1.
   
 0.839
CXCR4
C-X-C chemokine receptor type 4; Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Involved in the AKT signaling cascade (By similarity). Plays a role in regulation of cell migration, e.g. during wound healing. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Binds bacterial lipopolysaccharide (LPS) et mediates LPS- induced inflammatory response, including TNF secretion by monocytes (By similarity). Inv [...]
    
 0.799
XCR1
X-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family.
    
 0.762
CCR7
C-C chemokine receptor type 7; Belongs to the G-protein coupled receptor 1 family.
    
 0.761
CCR10
C-C motif chemokine receptor 10; Belongs to the G-protein coupled receptor 1 family.
    
 0.730
Your Current Organism:
Macaca fascicularis
NCBI taxonomy Id: 9541
Other names: M. fascicularis, Macaca cynomolgus, Macaca irus, crab eating macaque, crab-eating macaque, cynomolgus macaque, cynomolgus monkey, cynomolgus monkeys, long-tailed macaque
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