| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ENSMFAP00000013287 | IL1A | ENSMFAP00000013287 | ENSMFAP00000022267 | TNF receptor-associated factor. | Interleukin-1 alpha; Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells (By similarity). | 0.632 |
| ENSMFAP00000013287 | IL1B | ENSMFAP00000013287 | ENSMFAP00000022744 | TNF receptor-associated factor. | Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. | 0.645 |
| ENSMFAP00000013287 | IL1RAP | ENSMFAP00000013287 | ENSMFAP00000044686 | TNF receptor-associated factor. | Interleukin 1 receptor accessory protein. | 0.534 |
| ENSMFAP00000013287 | IL1RL1 | ENSMFAP00000013287 | ENSMFAP00000010356 | TNF receptor-associated factor. | Interleukin 1 receptor like 1. | 0.572 |
| ENSMFAP00000013287 | IL33 | ENSMFAP00000013287 | ENSMFAP00000031633 | TNF receptor-associated factor. | Interleukin 33. | 0.563 |
| ENSMFAP00000013287 | IRAK1 | ENSMFAP00000013287 | ENSMFAP00000002230 | TNF receptor-associated factor. | Interleukin 1 receptor associated kinase 1. | 0.980 |
| ENSMFAP00000013287 | IRAK4 | ENSMFAP00000013287 | ENSMFAP00000019428 | TNF receptor-associated factor. | Interleukin 1 receptor associated kinase 4. | 0.934 |
| ENSMFAP00000013287 | MYD88 | ENSMFAP00000013287 | ENSMFAP00000028875 | TNF receptor-associated factor. | Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...] | 0.964 |
| IL1A | ENSMFAP00000013287 | ENSMFAP00000022267 | ENSMFAP00000013287 | Interleukin-1 alpha; Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells (By similarity). | TNF receptor-associated factor. | 0.632 |
| IL1A | IL1B | ENSMFAP00000022267 | ENSMFAP00000022744 | Interleukin-1 alpha; Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells (By similarity). | Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. | 0.999 |
| IL1A | IL1RAP | ENSMFAP00000022267 | ENSMFAP00000044686 | Interleukin-1 alpha; Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells (By similarity). | Interleukin 1 receptor accessory protein. | 0.974 |
| IL1A | IL1RL1 | ENSMFAP00000022267 | ENSMFAP00000010356 | Interleukin-1 alpha; Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells (By similarity). | Interleukin 1 receptor like 1. | 0.722 |
| IL1A | IL1RN | ENSMFAP00000022267 | ENSMFAP00000016407 | Interleukin-1 alpha; Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells (By similarity). | Interleukin-1 receptor antagonist protein; Inhibits the activity of interleukin-1 by binding to receptor IL1R1 and preventing its association with the coreceptor IL1RAP for signaling. Has no interleukin-1 like activity (By similarity). Belongs to the IL-1 family. | 0.748 |
| IL1A | IL33 | ENSMFAP00000022267 | ENSMFAP00000031633 | Interleukin-1 alpha; Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells (By similarity). | Interleukin 33. | 0.755 |
| IL1A | IRAK1 | ENSMFAP00000022267 | ENSMFAP00000002230 | Interleukin-1 alpha; Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells (By similarity). | Interleukin 1 receptor associated kinase 1. | 0.756 |
| IL1A | IRAK4 | ENSMFAP00000022267 | ENSMFAP00000019428 | Interleukin-1 alpha; Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells (By similarity). | Interleukin 1 receptor associated kinase 4. | 0.677 |
| IL1A | MYD88 | ENSMFAP00000022267 | ENSMFAP00000028875 | Interleukin-1 alpha; Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells (By similarity). | Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...] | 0.816 |
| IL1A | TRAF6 | ENSMFAP00000022267 | ENSMFAP00000042496 | Interleukin-1 alpha; Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells (By similarity). | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. | 0.712 |
| IL1B | ENSMFAP00000013287 | ENSMFAP00000022744 | ENSMFAP00000013287 | Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. | TNF receptor-associated factor. | 0.645 |
| IL1B | IL1A | ENSMFAP00000022744 | ENSMFAP00000022267 | Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. | Interleukin-1 alpha; Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells (By similarity). | 0.999 |
