Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
NHLH2Nescient helix-loop-helix 2. (135 aa)    
Predicted Functional Partners:
TCF3
Transcription factor 3.
    
 0.678
LDB1
LIM domain binding 1.
    
 0.656
TCF12
Transcription factor 12.
    
 0.601
TCF4
Transcription factor 4.
    
 0.601
BEX1
Protein BEX1; Signaling adapter molecule involved in p75NTR/NGFR signaling. Plays a role in cell cycle progression and neuronal differentiation. Inhibits neuronal differentiation in response to nerve growth factor (NGF). May act as a link between the cell cycle and neurotrophic factor signaling, possibly by functioning as an upstream modulator of receptor signaling, coordinating biological responses to external signals with internal cellular states (By similarity).
      
 0.566
BEX2
Brain expressed X-linked 2.
      
 0.566
LMO2
LIM domain only 2.
    
 0.555
PCSK1
Proprotein convertase subtilisin/kexin type 1; Belongs to the peptidase S8 family.
    
 
 0.552
LDB2
LIM domain binding 2.
    
 0.550
ID1
Inhibitor of DNA binding 1, HLH protein.
    
 0.534
Your Current Organism:
Macaca fascicularis
NCBI taxonomy Id: 9541
Other names: M. fascicularis, Macaca cynomolgus, Macaca irus, crab eating macaque, crab-eating macaque, cynomolgus macaque, cynomolgus monkey, cynomolgus monkeys, long-tailed macaque
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