Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
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[Homology]
Score
JUNBJunB proto-oncogene, AP-1 transcription factor subunit. (347 aa)    
Predicted Functional Partners:
FOS
Fos proto-oncogene, AP-1 transcription factor subunit.
   
 0.999
FOSL2
FOS like 2, AP-1 transcription factor subunit.
   
 0.998
FOSB
FosB proto-oncogene, AP-1 transcription factor subunit.
   
 0.997
JUND
JunD proto-oncogene, AP-1 transcription factor subunit.
  
0.996
FOSL1
FOS like 1, AP-1 transcription factor subunit.
   
 0.992
MAPK9
Mitogen-activated protein kinase.
   
 0.980
MAPK10
Mitogen-activated protein kinase.
   
 0.978
MAPK8
Mitogen-activated protein kinase.
   
 0.978
EGR1
Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family.
   
 0.947
BATF
Basic leucine zipper ATF-like transcription factor.
   
 0.944
Your Current Organism:
Macaca fascicularis
NCBI taxonomy Id: 9541
Other names: M. fascicularis, Macaca cynomolgus, Macaca irus, crab eating macaque, crab-eating macaque, cynomolgus macaque, cynomolgus monkey, cynomolgus monkeys, long-tailed macaque
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