node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
FBXW5 | SPOCK1 | ENSMFAP00000008650 | ENSMFAP00000042288 | F-box and WD repeat domain containing 5. | SPARC (osteonectin), cwcv and kazal like domains proteoglycan 1. | 0.618 |
FBXW5 | TNFRSF19 | ENSMFAP00000008650 | ENSMFAP00000010596 | F-box and WD repeat domain containing 5. | TNF receptor superfamily member 19. | 0.407 |
IFRD2 | TNFRSF19 | ENSMFAP00000018660 | ENSMFAP00000010596 | Uncharacterized protein. | TNF receptor superfamily member 19. | 0.457 |
LGR5 | TNFRSF19 | ENSMFAP00000036977 | ENSMFAP00000010596 | Leucine rich repeat containing G protein-coupled receptor 5. | TNF receptor superfamily member 19. | 0.409 |
LHX2 | TNFRSF19 | ENSMFAP00000013334 | ENSMFAP00000010596 | LIM homeobox 2. | TNF receptor superfamily member 19. | 0.404 |
LINGO1 | MAG | ENSMFAP00000010806 | ENSMFAP00000024749 | Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1; Functional component of the Nogo receptor signaling complex (RTN4R/NGFR) in RhoA activation responsible for some inhibition of axonal regeneration by myelin-associated factors. Is also an important negative regulator of oligodentrocyte differentiation and axonal myelination. Acts in conjunction with RTN4 and RTN4R in regulating neuronal precursor cell motility during cortical development (By similarity). | Myelin associated glycoprotein. | 0.887 |
LINGO1 | OMG | ENSMFAP00000010806 | ENSMFAP00000013616 | Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1; Functional component of the Nogo receptor signaling complex (RTN4R/NGFR) in RhoA activation responsible for some inhibition of axonal regeneration by myelin-associated factors. Is also an important negative regulator of oligodentrocyte differentiation and axonal myelination. Acts in conjunction with RTN4 and RTN4R in regulating neuronal precursor cell motility during cortical development (By similarity). | Oligodendrocyte myelin glycoprotein. | 0.807 |
LINGO1 | RTN4R | ENSMFAP00000010806 | ENSMFAP00000032895 | Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1; Functional component of the Nogo receptor signaling complex (RTN4R/NGFR) in RhoA activation responsible for some inhibition of axonal regeneration by myelin-associated factors. Is also an important negative regulator of oligodentrocyte differentiation and axonal myelination. Acts in conjunction with RTN4 and RTN4R in regulating neuronal precursor cell motility during cortical development (By similarity). | Reticulon-4 receptor; Receptor for RTN4, OMG and MAG. Functions as receptor for the sialylated gangliosides GT1b and GM1 (By similarity). Besides, functions as receptor for chondroitin sulfate proteoglycans (By similarity). Can also bind heparin (By similarity). Intracellular signaling cascades are triggered via the coreceptor NGFR. Signaling mediates activation of Rho and downstream reorganization of the actin cytoskeleton. Mediates axonal growth inhibition (By similarity). May play a role in regulating axon regeneration and neuronal plasticity in the adult central nervous system. Pla [...] | 0.772 |
LINGO1 | TNFRSF19 | ENSMFAP00000010806 | ENSMFAP00000010596 | Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1; Functional component of the Nogo receptor signaling complex (RTN4R/NGFR) in RhoA activation responsible for some inhibition of axonal regeneration by myelin-associated factors. Is also an important negative regulator of oligodentrocyte differentiation and axonal myelination. Acts in conjunction with RTN4 and RTN4R in regulating neuronal precursor cell motility during cortical development (By similarity). | TNF receptor superfamily member 19. | 0.607 |
MAG | LINGO1 | ENSMFAP00000024749 | ENSMFAP00000010806 | Myelin associated glycoprotein. | Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1; Functional component of the Nogo receptor signaling complex (RTN4R/NGFR) in RhoA activation responsible for some inhibition of axonal regeneration by myelin-associated factors. Is also an important negative regulator of oligodentrocyte differentiation and axonal myelination. Acts in conjunction with RTN4 and RTN4R in regulating neuronal precursor cell motility during cortical development (By similarity). | 0.887 |
MAG | OMG | ENSMFAP00000024749 | ENSMFAP00000013616 | Myelin associated glycoprotein. | Oligodendrocyte myelin glycoprotein. | 0.949 |
MAG | RTN4R | ENSMFAP00000024749 | ENSMFAP00000032895 | Myelin associated glycoprotein. | Reticulon-4 receptor; Receptor for RTN4, OMG and MAG. Functions as receptor for the sialylated gangliosides GT1b and GM1 (By similarity). Besides, functions as receptor for chondroitin sulfate proteoglycans (By similarity). Can also bind heparin (By similarity). Intracellular signaling cascades are triggered via the coreceptor NGFR. Signaling mediates activation of Rho and downstream reorganization of the actin cytoskeleton. Mediates axonal growth inhibition (By similarity). May play a role in regulating axon regeneration and neuronal plasticity in the adult central nervous system. Pla [...] | 0.846 |
MAG | TNFRSF19 | ENSMFAP00000024749 | ENSMFAP00000010596 | Myelin associated glycoprotein. | TNF receptor superfamily member 19. | 0.459 |
OMG | LINGO1 | ENSMFAP00000013616 | ENSMFAP00000010806 | Oligodendrocyte myelin glycoprotein. | Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1; Functional component of the Nogo receptor signaling complex (RTN4R/NGFR) in RhoA activation responsible for some inhibition of axonal regeneration by myelin-associated factors. Is also an important negative regulator of oligodentrocyte differentiation and axonal myelination. Acts in conjunction with RTN4 and RTN4R in regulating neuronal precursor cell motility during cortical development (By similarity). | 0.807 |
OMG | MAG | ENSMFAP00000013616 | ENSMFAP00000024749 | Oligodendrocyte myelin glycoprotein. | Myelin associated glycoprotein. | 0.949 |
OMG | RTN4R | ENSMFAP00000013616 | ENSMFAP00000032895 | Oligodendrocyte myelin glycoprotein. | Reticulon-4 receptor; Receptor for RTN4, OMG and MAG. Functions as receptor for the sialylated gangliosides GT1b and GM1 (By similarity). Besides, functions as receptor for chondroitin sulfate proteoglycans (By similarity). Can also bind heparin (By similarity). Intracellular signaling cascades are triggered via the coreceptor NGFR. Signaling mediates activation of Rho and downstream reorganization of the actin cytoskeleton. Mediates axonal growth inhibition (By similarity). May play a role in regulating axon regeneration and neuronal plasticity in the adult central nervous system. Pla [...] | 0.752 |
OMG | TNFRSF19 | ENSMFAP00000013616 | ENSMFAP00000010596 | Oligodendrocyte myelin glycoprotein. | TNF receptor superfamily member 19. | 0.577 |
RTN4R | LINGO1 | ENSMFAP00000032895 | ENSMFAP00000010806 | Reticulon-4 receptor; Receptor for RTN4, OMG and MAG. Functions as receptor for the sialylated gangliosides GT1b and GM1 (By similarity). Besides, functions as receptor for chondroitin sulfate proteoglycans (By similarity). Can also bind heparin (By similarity). Intracellular signaling cascades are triggered via the coreceptor NGFR. Signaling mediates activation of Rho and downstream reorganization of the actin cytoskeleton. Mediates axonal growth inhibition (By similarity). May play a role in regulating axon regeneration and neuronal plasticity in the adult central nervous system. Pla [...] | Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1; Functional component of the Nogo receptor signaling complex (RTN4R/NGFR) in RhoA activation responsible for some inhibition of axonal regeneration by myelin-associated factors. Is also an important negative regulator of oligodentrocyte differentiation and axonal myelination. Acts in conjunction with RTN4 and RTN4R in regulating neuronal precursor cell motility during cortical development (By similarity). | 0.772 |
RTN4R | MAG | ENSMFAP00000032895 | ENSMFAP00000024749 | Reticulon-4 receptor; Receptor for RTN4, OMG and MAG. Functions as receptor for the sialylated gangliosides GT1b and GM1 (By similarity). Besides, functions as receptor for chondroitin sulfate proteoglycans (By similarity). Can also bind heparin (By similarity). Intracellular signaling cascades are triggered via the coreceptor NGFR. Signaling mediates activation of Rho and downstream reorganization of the actin cytoskeleton. Mediates axonal growth inhibition (By similarity). May play a role in regulating axon regeneration and neuronal plasticity in the adult central nervous system. Pla [...] | Myelin associated glycoprotein. | 0.846 |
RTN4R | OMG | ENSMFAP00000032895 | ENSMFAP00000013616 | Reticulon-4 receptor; Receptor for RTN4, OMG and MAG. Functions as receptor for the sialylated gangliosides GT1b and GM1 (By similarity). Besides, functions as receptor for chondroitin sulfate proteoglycans (By similarity). Can also bind heparin (By similarity). Intracellular signaling cascades are triggered via the coreceptor NGFR. Signaling mediates activation of Rho and downstream reorganization of the actin cytoskeleton. Mediates axonal growth inhibition (By similarity). May play a role in regulating axon regeneration and neuronal plasticity in the adult central nervous system. Pla [...] | Oligodendrocyte myelin glycoprotein. | 0.752 |